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Paper Information

Journal:   IRANIAN HEART JOURNAL (IHJ)   SUMMER 2007 , Volume 8 , Number 2; Page(s) 44 To 50.
 
Paper: 

EFFECT OF FOLIC ACID ON SERUM HOMOCYSTEINE AND MORBIDITY IN PATIENTS WITH CHRONIC CORONARY ARTERY DISEASE

 
 
Author(s):  JALALI F., HAJIAN TILAKI K.O.*
 
* DEPT. OF SOCIAL MEDICINE AND HEALTH, BABOL FACULTY OF MEDICINE, BABOL UNIVERSITY OF MEDICAL SCIENCES, BABOL, IRAN
 
Abstract: 

Background- In addition to traditional cardiovascular risk factors, high levels of plasma homocysteine has been documented recently as independent risk factors for atherosclerosis. The probable mechanism is through endothelial dysfunction. Roughly 10% of the population with coronary artery disease (CAD) may have hyper-homocysteinernia. Since folic acid is a potential factor in lowering plasma homocysteine and dietary intake of folic acid is not sufficient, it needs to be prescribed to CAD patients as a supplement. The purpose of this study is to assess the effect of folic acid on plasma homocysteine levels and on morbidity in stable CAD patients.
Methods- In this prospective interventional study, we recruited 52 stable CAD patients; the plasma levels of homocysteine, folic acid and vitamin B12 were measured. The morbidity-related indices (the number of sublingual TNGs per week, typical anginal chest pain per week, the number of cardiovascular-related hospitalizations in the previous 3 months, functional class and ECG changes) were determined. All patients received 2 mg oral folic acid daily for 3 months. At the end of the study, the level of homocysteine and morbidity were determined.
Results- Folic acid supplementation for 3 months was associated with a decrease in homocysteine level by 44% (P=0.000) We did not observe a significant change in levels of serum folic acid. There were significant declines in all morbidity indices including TNG consumption, frequency of chest pain, functional class and hospitalizations (P=0.001).
Conclusion- The findings indicate that 2 mg folic acid orally daily for 3 months is associated with a decrease in homocysteine level and morbidity in CAD patients.

 
Keyword(s): SERUM HOMOCYSTEINE, FOLIC ACID, MORBIDITY, CORONARY ARTERY DISEASE
 
 
References: 
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+ Click to Cite.
APA: Copy

JALALI, F., & HAJIAN TILAKI, K. (2007). EFFECT OF FOLIC ACID ON SERUM HOMOCYSTEINE AND MORBIDITY IN PATIENTS WITH CHRONIC CORONARY ARTERY DISEASE. IRANIAN HEART JOURNAL (IHJ), 8(2), 44-50. https://www.sid.ir/en/journal/ViewPaper.aspx?id=101543



Vancouver: Copy

JALALI F., HAJIAN TILAKI K.O.. EFFECT OF FOLIC ACID ON SERUM HOMOCYSTEINE AND MORBIDITY IN PATIENTS WITH CHRONIC CORONARY ARTERY DISEASE. IRANIAN HEART JOURNAL (IHJ). 2007 [cited 2021May17];8(2):44-50. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101543



IEEE: Copy

JALALI, F., HAJIAN TILAKI, K., 2007. EFFECT OF FOLIC ACID ON SERUM HOMOCYSTEINE AND MORBIDITY IN PATIENTS WITH CHRONIC CORONARY ARTERY DISEASE. IRANIAN HEART JOURNAL (IHJ), [online] 8(2), pp.44-50. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101543.



 
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