Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   SUMMER 2007 , Volume 14 , Number 2 (SN 44); Page(s) 40 To 44.
 
Paper: 

THE COMPARISON OF EFFICACY OF TRICYCLIC ANTIDEPRESSANT WITH AND WITHOUT NON STEROIDAL ANTI INFLAMMATORY DRUGS IN CHRONIC LOW BACK PAIN

 
 
Author(s):  YAVARIKIA A.R.*
 
* DEPARTMENT OF ORTHOPEDICS, SCHOOL OF MEDICINE HAMADAN UNIVERSITY OF MEDICAL SCIENCES & HEALTH SERVICES, HAMADAN , IRAN
 
Abstract: 

Introduction & Objectives: Low back pain (LBP) is one of common medical problems with several accepted medical modalities such as drugs, physiotherapy, surgery, etc. We studied the efficacy of tricyclic antidepressant (TCA), and tricyclic antidepressant plus non steroidal anti inflammatory drugs (TCA + NSAID) in 200 patients with chronic LBP.
Materials & Methods: In an experimental clinical trial study on patients with chronic low back pain without organic findings, patients were divided in two groups of 100 cases. At certain times the response to treatment protocols were collected and compared using VAS system. Patient's data including age, sex, smoking and response to treatment were recorded and analyzed using chi-square, t-tests, ANOVA and SPSS software.
Results: 83 (41.5%) of patients were males and 117 (58.5%) were females. The age range was 21 to 75 (mean age 43.1
±14.1y) there was no meaning full statistical difference in demographic characteristics such as age, sex (respectively p=0.66, p=0.78) the ultimate pain was less (p<0.05) in patients receiving TCA+NSAID compared to the other group. Two methods of quantization of pain had not any meaning full statistical difference (p>0.05).
Conclusion: TCA prescription is an efficient method of treatment of low back pain with or without NSAIDS. But using NSAID+TCA will be almost more powerful and efficient method in the long term period.

 
Keyword(s): ANTI-DEPRESSIVE AGENTS, TRICYCLIC, ANTI-INFLAMMATORY AGENTS LOW BACK PAIN, PAIN MEASUREMENT
 
References: 
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