Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   SUMMER 2007 , Volume 14 , Number 2 (SN 44); Page(s) 28 To 34.
 
Paper:  COMPARISON OF THE EFFECT OF VERAPAMIL, NIFEDIPINE AND DILTIAZEM ON PENTYLENETETRAZOLE-INDUCED CLONIC SEIZURE THRESHOLD IN MICE
 
Author(s):  KHAYAT NOURI M.H.*
 
* DEPARTMENT OF BASIC SCIENCES, ISLAMIC AZAD UNIVERSITY, TABRIZ, IRAN
 
Abstract: 

Background & Objective: Verapamil, nifedipine and diltiazem are calcium channel blockers widely used as a variety of cardiovascular ailment in humans. A number of studies have shown that calcium channel blockers have anticonvulsant effect in a range of animal seizure models (but not all animals). The aim of this study was to investigate the effects of verapamil, nifedipine and diltiazem on pentylenetetrazole-induced seizure threshold and to compare these effects in mice.
Materials & Methods: In this experimental study, mice were pretreated intraperitoneally with vehicle or calcium channel blockers (0.5, 1, 2.5, 5, 10 and 20 mg/kg) before intravenously the determination of the pentylenetetrazole-induced seizure threshold.
Results: Our results showed that the pentylenetetrazole-induced seizure threshold was 33.4
±0.42 mg/kg in control group. In animals pretreated with verapamil, nifedipine and diltiazem the pentylenetetrazole-induced seizure threshold dose dependently increased.
Compare between calcium channel blockers showed that diltiazem and verapamil had greatest and least effects, respectively.
Conclusion: Our results suggest that the Ca2+ channel blockers possess anticonvulsant activity probably via an antagonism effect on voltage-gated Ca2+channels.

 
Keyword(s): DILTIAZEM, NIFEDIPINE, PENTYLENETETRAZOLE, SEIZURE, VERAPAMIL
 
References: 
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