Paper Information

Journal:   JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL   SUMMER 2007 , Volume 6 , Number 2 (53); Page(s) 168 To 174.
 
Paper: 

EVALUATION OF THE EFFECT OF CHRONIC ORAL ADMINISTRATION OF WITHANIA SOMNIFERA ROOT ON PAIN SCORE IN MALE DIABETIC RATS

 
 
Author(s):  ROUGHANI M.*, BALUCHNEJADMOJARAD TOURANDOKHT, KHALILI M., MAHDAVI SALIMI S.F.
 
* DEPARTMENT OF PHYSIOLOGY AND MEDICINAL PLANT RESEARCH CENTER, SCHOOL OF MEDICINE, SHAHED UNIVERSITY, TEHRAN
 
Abstract: 

Objective: Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. Considering the anti-diabetic potential effect of the medicinal plant Withania somnifera (WS) (Ashwagandha), this study was designed to investigate the analgesic effect of WS on formalin-induced nociceptiye responses in diabetic rats.
Subjects and Methods: Rats were divided into six groups: non-treated control, WS-treated control, streptozocin (STZ)-induced diabetic, sodium salicylate (SS)-treated control, diabetic and WS-treated diabetic groups. For induction of diabetes, STZ (60 mg/Kg, i.p.) was administered as a single dose. The treatment groups received orally Withania somnifera -mixed rat pellet (6.25%) for two months.
Results: The results showed that diabetic rats exhibited a higher score of pain at both phases of the formalin test and WS-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (p<0.05). While, SS administration significantly reduced pain score only at chronic phase of the test in the diabetic group (p<0.01).
Conclusion: Taken together, these results indicate that two-month administration of Withania somnifera could attenuate nociception in an experimental model of diabetes mellitus and this may be considered as a treatment for painful diabetic neuropathy.

 
Keyword(s): WITHANIASOMNIFERA, PAIN, STREPTOZOCIN, EXPERIMENTAL DIABETES, RAT
 
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