Paper Information

Journal:   JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL   SUMMER 2007 , Volume 6 , Number 2 (53); Page(s) 210 To 218.
 
Paper:  EFFECT OF REBOXETINE ON REDUCTION OF ANXIETY SYMPTOMS IN DEPRESSED CHILDREN AND ADOLESCENTS
 
Author(s):  TASHAKORI A.*, ARABGOL F., PANAGHI L.
 
* DEPARTMENT OF PSYCHIATRY, AHWAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHWAZ
 
Abstract: 

Objective: Anxiety is common in depressed children and adolescents. Reboxetine is only norepinephrine reuptake inhibitor that may be useful for depressed adults with co-morbid anxiety. Thus this study is carried out to assess effect of reboxetine on anxiety symptoms of depressed children and adolescents.
Subjects and Methods: This open trial is performed in twenty, outpatients with major depressive or dysthymic disorder with anxiety symptoms. Easy sampling was used. Dose of reboxetine was 4.36
±1.20 mg/day. Hamilton Anxiety Rating Scale (HARS) was used to assess anxiety.
Results: The 20 patients selected in studies (7-17 years old, mean 12.80
± 2.82 years) (female=10, male=10). Following reboxetine administration, HARS score and its somatic and psychic factors were significantly reduced (p<0.001). In addition, anxiety symptoms were reduced about 43.22% during first week and 69.63% after 8 weeks of treatment.
Conclusion: Reboxetine does not exacerbate anxiety symptoms but quickly improves them during first week of administration. The effectiveness increases with prolonged use. Double blind -placebo controlled studies are needed to establish this conclusion.

 
Keyword(s): ANXIETY SYMPTOMS, DEPRESSION, CHILDREN, ADOLESCENTS, REBOXETINE
 
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