Paper Information

Journal:   HORMOZGAN MEDICAL JOURNAL   SPRING 2006 , Volume 10 , Number 1; Page(s) 23 To 28.
 
Paper: 

OPIOID RECEPTORS ROLE ON ANTI-NOCICEPTIVE EFFECTS OF THE AQUEOUS EXTRACTS OF MELISSA OFFICINALIS IN MICE

 
 
Author(s):  MILADI GORJI H.*, RASHIDIPOUR A., VAFAEI A.A., TAHERIAN ABAS ALI
 
* DEPARTMENT OF PHYSIOLOGY, MEDICAL SCHOOL RESEARCH CENTER SEMNAN UNIVERSITY OF MEDICAL SCIENCES SEMNAN, IRAN
 
Abstract: 

Melissa Officinalis (MO) overgrows in different parts of Iran. In previous studies, ethanol extract of aerial parts (leaf & stem) of MO showed anti-nconvulsant and sedative effects in rats. This study was designed to evaluate anti-nociceptive effects in different doses of aqueous decoction extracts of MO and the role of opioid receptors in rats.
Methods: In this experimental study, 63 male mice (weighing 25-30g) in Tail Flick model were examined. Different doses of extract (5, 10, 25, 50 mg/kg IPMO) were injected to the separate groups and saline (10ml/kg-IP) was injected intrapeditoneal in control group. In four groups the role of opioid receptors (Naloxone 2mg.kg) was designed to evaluate anti-nociceptive effects in the aqueous decoction extracts of MO (5mg/kg) and 25 minutes after the injection the anti-nociceptive effect was evaluated. Analysis of variance was used to analysis the data.
Results: The results showed that average time of Tail Flick had significant difference in two groups (P<0.0001) but the test groups had no significant difference in different doses. Based on the results, naloxone caused reduction in anti-nociceptive effects of 5 mg/kg Melissa Officinalis dose (P<0.0001).
Conclusion: It is concluded that the aqueous extract of MO has anti-nociceptive activity which is not dose related, and is probably related to opioid receptors.
Determination of other receptors which may have anti-nociceptive activity needs further investigation.

 
Keyword(s): RECEPTORS, OPIOID, RATS, ANALGESICS, MEDICINE, HERBAL
 
References: 
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