Paper Information

Journal:   PHARMACEUTICAL SCIENCES   SUMMER 2007 , Volume - , Number 2; Page(s) 39 To 46.
 
Paper: 

EFFECT OF AMLODIPINE ON KIDNEY TISSUE CONCENTRATION OF ENDOTHELIN IN RABBITS RECEIVING ATHEROGENIC DIET

 
 
Author(s):  MOHAMMADI M.*, MIRZAEI F., ASLANABADI N.
 
* DRUG APPLIED RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Objectives: Different factors are in involved in inducing and progressing of atherosclerosis. One of these factors is endothelin-1. Since in atherosclerotic vessels obvious and certain changes with abnormality in transferring of calcium ions are seen, some researchers suggested that calcium channel blockers can slowdown the process of atherosclerosis.
Methods: 36 male Newsland white rabbits were divided into four groups: The normal control group, normal group receiving amlodipine, high-cholesterol diet group and high-cholesterol diet with amlodipine group. After 8 weeks all animals anesthetized and blood and tissues samples were colleted.
Results: The levels of cholesterol and triglyceride in groups of high-cholesterol diet comparison to control group increased significantly (p< 0.01). Amlodipine consumption in eight weeks reduced significantly (p< 0/01) plasma endothelin-1 levels in both of high-cholesterol diet plus amlodipine and amlodipine groups. Amlodipine consumption caused significant reduction (p<0/01) in the level of endothelin-1 in heart tissue of high-cholesterol diet plus amlodipine group but did no effect on reduction of heart tissue endothelin-1 in amlodipine group.
Conclusion: High-cholesterol diet caused enhancing of plasma and renal tissue endothelin-1 and amlodipine reduced plasma and tissue endothelin-1 levels in high-cholesterol diet group. In conclusion amlodipine treatment could have positive effects in pathology of atherosclerotic renal arteries.

 
Keyword(s): AMLODIPINE, ENDOTHELIN-1, ATHEROSCLEROTIC RABBITS
 
References: 
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