Paper Information

Journal:   PHARMACEUTICAL SCIENCES   SUMMER 2007 , Volume - , Number 2; Page(s) 23 To 29.
 
Paper: 

THE EFFECTS OF TOTAL EXTRACT AND ITS DIFFERENT FRACTIONS OF IRANIAN BLACK ORTHODOX TEA ON WEIGHT, FOOD INTAKE AND BLOOD SUGAR IN TYPE I DIABETIC RATS

 
 
Author(s):  OSTAD RAHIMI A.R., DELAZAR A., ALIPOUR B.*, MESGARI M., ASNAASHARI S., VATAN A.M., ALIPOUR AZHIRI S., SAFAIAN A.A.R.
 
* SCHOOL OF HEALTH & NUTRITION, TABRIZ UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Objectives: Diabetes is one the most common endocrine disorders, obesity, improper nutrition, and inactivity was considered as proposing factors. Historically plant extracts are used for diabetes control. This study was implemented to determine the effect of total and different fraction of Iranian black orthodox tea on weight, food intake and blood sugar in type I diabetic rats.
Methods: This study was conducted on 56 rats which were randomly divided in to 8 groups (7 rats in each group). The weight of rats was 200 – 250 gr. Group 1 and 2 was non-diabetic, groups 3 – 8 were diabetic, and diabetes was induced with intraperitoneal injection of streptozotocin 60mg/kg. Group 1 to 8 received carrier, total extract, carrier, total extract, methanol fractions of 20%, 40%, 60% and 80% plus 100% respectively. Blood sugar was measured beginning and end of intervention, weight and food intake was measured each week during intervention (5 times). Data was analyzed by using one and two ways ANOVA, repeated measure and nested variance.
Results: Food intake and weight was reduced, in 40% fraction received group, significantly more than other groups (p=0.000).also total extract decreased food intake significantly (p=0.000). There were no significant differences between other groups. Change in Mean blood sugar between groups during intervention was not found statistically significant.
Conclusion: It can be concluded that injection of total extract and 40% fraction of black tea had positive effect on decreasing of food intake in diabetic rats and prevention of obesity. Therefore consumption of black tea might prevent from diabetes and its complications.

 
Keyword(s): BLACK TEA, DIABETES, RAT
 
References: 
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