Paper Information

Journal:   PHARMACEUTICAL SCIENCES   SUMMER 2007 , Volume - , Number 2; Page(s) 15 To 21.
 
Paper: 

INFLUENCE OF THE TOTAL EXTRACT OF HYPERICUM SCABRUM AND CALCIC AND MAGNESIC SULFATE MINERAL WATER ON LIPID PROFILE IN RAT

 
 
Author(s):  HABIBIASL B.*, NEMATI M., DELAZAR A., MESGARI M., VATANKHAH A.M., SOLTANI A.A.F.
 
* FACULTY OF PHARMACY, TABRIZ UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Objectives: Mineral waters and some extract of plants contain some elements and components such as flavonoids that are therapeutic. In this study the effect of the total extract of Hypericum Scabrum and calcic and magnesic sulfate mineral water on lipid profile of in hypercholesterolemic rats were compared.
Methods: 48 male SD rats (100-150 g) were selected. They were divided to 8 groups of 6 rats and seven groups received cholesterol rich diet and one group received normal diet as control for the first 60 days. Then the diet of rats was changed for the second 60 days.:Group1: normal diet, City water, DMSO (ip), Group2: normal diet, Mineral water, DMSO (ip), Group3: normal diet, City water, Atorvastatin (0.5mg/kg, ip), Group4: hypercholesterolemic diet, City water, normal saline (ip),Group5: hypercholesterolemic diet, City water, DMSO (ip), Group6: hypercholesterolemic diet, Mineral water, DMSO (ip),Group7: normal diet, City water, Scabrum (4mg/kg, ip), Group8: normal diet, City water, Scabrum (12mg/kg, ip) and again at the end of the second period the blood sample was taken from rats, eyes.
Results: the results of tests showed that the difference in lipid profile were significant for all groups in comparison with high cholesterol control group (P<0.001) the difference in serum magnesium level by Mineral water was not significant in comparison with other groups (P>0.05).
Conclusions: According to the results of this study it seems that the study about hypocholesterolemic effects of Hypericum Scabrum and mineral water in human kind may be useful.

 
Keyword(s): HYPERLIPIDEMIA, HYPERICUM SCABRUM, MINERAL WATER, ATORVASTATINE
 
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