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Paper Information

Journal:   SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES JOURNAL   FALL 2007 , Volume 9 , Number 3; Page(s) 1 To 9.
 
Paper: 

ANTI SPASMOLYTIC EFFECT OF GLYCYRRHIZA GLABRA LEAF ON RAT ILEUM CONTRACTIONS

 
 
Author(s):  GHARIB NASERI MOHAMMAD KAZEM*, ARABIAN Z., GHARIB NASERI ZAHRA
 
* PHYSIOLOGY DEPT., AHVAZ UNIV. OF MED. SCI. IRAN
 
Abstract: 

Background and aim: Glycyrrhiza glabra is a type of plant that a lot of researches have been carried out on components and properties of its licorice but the effect of its leaf extract has not been evaluated. Therefore, this study was aimed to investigate the effect of Glycyrrhiza glabra leaf extract on rat ileum contractions.
Methods: In this experimental study, the terminal portion of ileum from male Wistar rat was contracted under 1 gram tension by 60 mM KCl and/or 10
mM carbachol and then the effect of aquatic extraction of Glycyrrhiza glabra on the contractions was assessed. The new portions of the ileum were separately incubated with propranolol (1mM), naloxone (1mM), inhibitor of nitric oxide synthetize (L-NAME) (100mM), glibenclamide (10mM) and tetraethyl ammonium (1mM) and the tissue spasm and antispasmodic effect of the extract were recorded. Data were analyzed using one and two way analysis of variance and post hoc LSD tests.
Results: Cumulative concentrations of the extract (0.0625-0.5mg/ml) reduced the ileum contractions induced by KCl and carbacole, dose-dependently (P<0.001). Incubation of the tissue with propranolol, naloxone, L-NAME, and tetraethyl ammonium did not reduce the antispasmodic effect of the extract, but it was reduced by glibenclamide (0.125mg/ml). In Tyrode-containing solution, without calcium and with high concentrations of potassium (60
mM), the cumulative concentrations of CaCl2 (0.5-8mM) contracted the ileum and the extract (0.0156-0.0625mg/ml) reduced the induced contractions (P<0.001).

Conclusion: Based on our results, the aqueous extract of Glycyrrhiza glabra inhibited the ileum contractions without involving b-adrenergic, opioid, and tetraethyl ammonium receptors. Calcium channels were involved in the main part of this inhibitory effect and probably activation of ATP-dependent potassium channels partially was involved in this process.

 
Keyword(s): ANTI SPASMOLYTIC, CARBACOLE, GLYCYRRHIZA GLABRA LEAF, ILEUM, RAT
 
 
References: 
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Click to Cite.
APA: Copy

GHARIB NASERI, M., & ARABIAN, Z., & GHARIB NASERI, Z. (2007). ANTI SPASMOLYTIC EFFECT OF GLYCYRRHIZA GLABRA LEAF ON RAT ILEUM CONTRACTIONS. SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 9(3), 1-9. https://www.sid.ir/en/journal/ViewPaper.aspx?id=101302



Vancouver: Copy

GHARIB NASERI MOHAMMAD KAZEM, ARABIAN Z., GHARIB NASERI ZAHRA. ANTI SPASMOLYTIC EFFECT OF GLYCYRRHIZA GLABRA LEAF ON RAT ILEUM CONTRACTIONS. SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES JOURNAL. 2007 [cited 2021May06];9(3):1-9. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101302



IEEE: Copy

GHARIB NASERI, M., ARABIAN, Z., GHARIB NASERI, Z., 2007. ANTI SPASMOLYTIC EFFECT OF GLYCYRRHIZA GLABRA LEAF ON RAT ILEUM CONTRACTIONS. SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES JOURNAL, [online] 9(3), pp.1-9. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101302.



 
 
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