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Paper Information

Journal:   HORMOZGAN MEDICAL JOURNAL   WINTER 2007 , Volume 10 , Number 4; Page(s) 311 To 319.
 
Paper: 

DECREASE IN BLOOD FLOW AND TEMPERATURE OF RAT KNEE JOINT BY CALCIUM CHANNEL BLOCKERS IN CHRONIC INFLAMMATION

 
 
Author(s):  KHAKSARI HADAD M.*, RAHMANI M.R., ASADI KARAM GH.R., HAJIZADEH S., SHAHRANI M.
 
* DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Abstract: 

Introduction: The Blood flow increases in the inflamed joint induced by Complete Freund's Adjuvant (CFA). Since the anti-inflammatory effect of calcium channel blockers have been shown in pervious studies, the present study investigates the role of these blockers on the blood flow and temperature (inflammation indices) in inflamed knee joint induced by CFA.

Methods: This experimental study was carried out in 8 groups of adult male rats. In group I, 0.2 ml of CFA solution was injected into the right knee, and group II received the same volume of normal saline. Group III to VIII received the same volume of CFA solution, but seven days after injection of CFA to the end of study, received the following drugs orally by oropharyngeal tubes. Group III dimethylsulfoxide (the drugs solvent), group IV and V received low dose (100 mg/kg) of verapamil and nifedipine respectively. Group VI and VII received high dose (800 mg/kg) of verapamil and nifedipine respectively, and group VIII was treated with ibuprofen (15mg/kg). The changes in blood flow and local temperature of the animal's knee joint were measured for 28 days after CFA injection.

Results: CFA injection increased blood flow significantly in all 28 days compared to day zero, where as at seventh day increase in blood flow was 121.8±6.1 percent. Low dose of verapamil and nifedipine increased CFAinduced blood flow. The high dose of verapamil and nifedipine also diminished the blood flow of the knee. The inhibition effect of these blockers on knee joint blood flow was comparable to ibuprofen. Decrease in temperature by different doses of verapamil and nifedipine were not significant.
Conclusion: The results of this study show that calcium channel blockers inhibit the increased blood flow and temperature in chronic inflammation induced by CFA injection in the inflamed region. So these blockers possibly reduce the chronic inflammation by this mechanism.

 
Keyword(s): RATS, KNEE JOINT, BLOOD FLOW VELOCITY, INFLAMMATION, CALCIUM CHANNEL BLOCKERS
 
References: 
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