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Paper Information

Journal:   KOWSAR MEDICAL JOURNAL   WINTER 2007 , Volume 11 , Number 4; Page(s) 315 To 324.
 
Paper: 

THE EFFECTS OF TOPIRAMATE ON MORPHINE SENSITIZATION IN MICE

 
 
Author(s):  HOUSHMANDI Z., SAHRAEI HEDAYAT*, GHOSHOUNI H., FATEMI M., SHAMS J.
 
* DEPARTMENT OF PHYSIOLOGY AND BIOPHYSICS FACULTY OF MEDICINE, BAQIYATALLAH (A.S.) UNIVERSITY OF MEDICAL SCIENCES, AND BEHAVIORAL SCIENCES RESEARCH CENTER TEHRAN, IR. IRAN
 
Abstract: 

Objective: In the present study attempts were made to further identify the effects of topiramate on the acquisition and expression of morphine-induced conditioned place preference in morphine-sensitized mice.
Materials and Methods: Male Swiss-Webster mice (20-30 g) were used in this study and un-biased place conditioning paradigm was applied for this purpose. In a pilot study, the effects of morphine on place conditioning paradigm were assessed in morphine-nave animals for evaluation of ineffective doses of the drug.
Results: Administration of one dose daily morphine (5 mg/kg) for 3 days followed by five days rest, in order to develop sensitization, enhanced the conditioning induced by ineffective morphine (0.25, 0.5 and 1 mg/kg). Injections of topiramate (20, 80 and 120 mg/kg, i.p.) reduced both the acquisition and expression of morphine CPP in morphinesensitized animals. Topiramate (20, 80 and 120 mg/kg, i.p.) by itself did not induce place preference or place aversion in the mice.
Conclusion: It can be concluded that to piramate administration leads to inhibition of morphine sensitization, which may be due to glutamate and/or GABAergic mechanisms. In addition, it seems that topiramate may be useful for treatment of psychological dependence to opioids.

 
Keyword(s): CONDITIONED PLACE PREFERENCE, MORPHINE, TOPIRAMATE, DRUG SENSITIZATION, MICE
 
References: 
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