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Journal:   BINA   SPRING 2006 , Volume 11 , Number 3 (44); Page(s) 307 To 312.
 
Paper: 

Short-Term Vs Long-Term Systemic Corticosteroid In Ocular Toxoplasmosis

 
 
Author(s):  Razmjou H., Kian Ersi F., Khademi M.R., Akhlaghi M.R.
 
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Abstract: 
Purpose: To compare the effects of short-term and long-term systemic corticosteroids in the treatment of confirmed ocular toxoplasmosis.Methods: This randomized comparative clinical trial was performed on 69 patients with confirmed active ocular toxoplasmosis with typical clinical manifestations. The subjects were randomly assigned to receive either 10 days (group A, 33 cases) or 4-6 weeks (group B, 36 cases) of systemic corticosteroids in addition to classic antibiotic therapy. All patients were visited and followed weekly until complete improvement of vision. Mean visual acuity, inflammatory cell countin the vitreous, lesion size and severity of the condition were compared between the two groups.Results: There was no statistically significant difference between the two group, regarding mean values of visual acuity in Log MAR (before; group A: 0.24±0.6, group B: 0.280±0.07, P=0.43 and after; group A: 0.11±0.08, group B: 0.06±0.07, P=0.09), vitreal inflammatory cell count (before; group A: 1.8±0.56, group B: 1.9±0.60, P=0.45 and after; group A: 1.5±0.65, group B: 1.5±0.5, p=0.94), and size of the lesions in disc diameter (before; group A: 0.94±0.37, group B: 1.03±0.37, P=0.49 and after; group A: 0.94±0.44, group B: 1.12±0.38, P=0.4).Conclusion: The study revealed that there is no significant difference between the effects of short term and long-term systemic corticosteroid therapy in the treatment of ocular toxoplasmosis. It is reasonable to perform an equivalence trial study on this issue.
 
Keyword(s): OCULAR TOXOPLASMOSIS, CORTICOSTEROID, LONG-TERM, SHORT-TERM
 
 
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APA: Copy

RAZMJOU, H., & KIAN ERSI, F., & KHADEMI, M., & AKHLAGHI, M. (2006). SHORT-TERM VS LONG-TERM SYSTEMIC CORTICOSTEROID IN OCULAR TOXOPLASMOSIS. BINA, 11(3 (44)), 307-312. https://www.sid.ir/en/journal/ViewPaper.aspx?id=91843



Vancouver: Copy

RAZMJOU H., KIAN ERSI F., KHADEMI M.R., AKHLAGHI M.R.. SHORT-TERM VS LONG-TERM SYSTEMIC CORTICOSTEROID IN OCULAR TOXOPLASMOSIS. BINA. 2006 [cited 2022May23];11(3 (44)):307-312. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=91843



IEEE: Copy

RAZMJOU, H., KIAN ERSI, F., KHADEMI, M., AKHLAGHI, M., 2006. SHORT-TERM VS LONG-TERM SYSTEMIC CORTICOSTEROID IN OCULAR TOXOPLASMOSIS. BINA, [online] 11(3 (44)), pp.307-312. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=91843.



 
 
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