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Paper Information

Journal:   ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)   SPRING 2007 , Volume 10 , Number 1 (38); Page(s) 71 To 78.
 
Paper: 

SURVEY ON BIOCHEMICAL ALTERATIONS LEADING TO RENAL BONE DISEASE IN HEMODIALYSIS PATIENTS

 
 
Author(s):  SAROUKHANI M.*
 
* QAZVIN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: Secondary hyperparathyroidism (SHPT) is one of the serious complications in patients with chronic kidney disease (CKD). This study aimed to identify biochemical alterations of renal bone disease in hemodialysis patients of Qazvin province.
Materials and Methods: In a descriptive study, fasting blood samples of arterio-venul shunt, before starting hemodialysis, were taken from all CKD patients and Ca++, P- and ALP were measured by colorimetric methods and PTH by IRMA method. Descriptive statistics was used to present data.
Results: In 4% of cases there were no abnormalities of mentioned parameters but in 96% of patients one or more parameters were abnormal. The most prevalent abnormality was related to P-- (increased) and the least one to ALP (increased). 51% of patients had raised PTH level (hyperparathyroidism) and higher abnormalities of other biochemical parameters. No differences were seen in the mean of age, duration and number of hemodialysis and also sex ratio of hyperparathyroid patients and all studied patients.
Conclusion: The Biochemical and hormonal results revealed a predominance of mild to moderate secondary hyperparathyroidism and renal bone disease in CKD patients, so there is a need to control the disease with specific treatments.

 
Keyword(s): RENAL BONE DISEASE, CALCIUM, PHOSPHOROUS, ALKALINE PHOSPHATASE, PARATHORMONE
 
References: 
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