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Paper Information

Journal:   IRANIAN JOURNAL OF PATHOLOGY (IJP)   WINTER 2006 , Volume 1 , Number 1; Page(s) 17 To 20.
 
Paper: 

RELATIONSHIP BETWEEN GRADE AND MDM2 ONCOPROTEIN OVEREXPRESSION IN TRANSITIONAL CELL CARCINOMA OF THE URINARY BLADDER

 
 
Author(s):  JALALI NADOUSHAN M.R.*, GHORBANIAN A.A., TAHERI T.
 
* DEPT. OF PATHOLOGY, MOSTAFA KHOMEINI HOSPITAL, TEHRAN, IRAN
 
Abstract: 

Objective: Transitional cell carcinoma (TCC) of the urinary bladder is the second common cancer of the genitourinary tract. Several parameters such as clinical and pathological parameters, molecular factors, and etc play a role in determination of prognosis and type of treatment. In this research study, the relationship between grade and MDM2 oncoprotein overexpression in TCC of bladder was evaluated.

Material and Methods: This cross-sectional study was carried out on 75 paraffin embedded tissue blocks (deposited in Pathology Department) from patients with TCC of urinary bladder from 2002 to 2005. In this respect, 3 mm sections were taken from each block. In one of the sections, grade of tumor was determined according to WHO/ISUP criteria using hematoxylin-eosin staining method. In another section, percent of MDM2 positive cells were determined by microscopic observation of 100 cells in each section using immunohistochemical technique and specific antibody.

Results: Mean of MDM2 positive cells was %9.08±4.7. In addition, mean of MDM2 positive cells in low malignant potential tissue (grade I), low grade tissue (grade II), and high grade tissue (grade III) was %3.6±2.2, %8.2±3.5, and %13.1±3.4 respectively. Meanwhile, a significant relationship was found out between grade and overexpression of MDM2 oncoprotein (p=0.012).

Conclusion: Overexpression of MDM2 oncoprotein exhibits a direct relationship with grade of TCC of the urinary bladder. The obtained results were consistent with the most previous studies. Therefore, through performing studies with a greater follow-up and entailing a larger population of patients, overexpression of MDM2 oncoprotein could be used as a prognostic parameter in TCC of urinary bladder.
 
Keyword(s): TRANSITIONAL CELL CARCINOMA OF THE URINARY BLADDER (TCC), GRADE, MDM2 ONCOPROTEIN
 
 
References: 
 
Citations: 
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APA: Copy

JALALI NADOUSHAN, M., & GHORBANIAN, A., & TAHERI, T. (2006). RELATIONSHIP BETWEEN GRADE AND MDM2 ONCOPROTEIN OVEREXPRESSION IN TRANSITIONAL CELL CARCINOMA OF THE URINARY BLADDER. IRANIAN JOURNAL OF PATHOLOGY (IJP), 1(1), 17-20. https://www.sid.ir/en/journal/ViewPaper.aspx?id=88893



Vancouver: Copy

JALALI NADOUSHAN M.R., GHORBANIAN A.A., TAHERI T.. RELATIONSHIP BETWEEN GRADE AND MDM2 ONCOPROTEIN OVEREXPRESSION IN TRANSITIONAL CELL CARCINOMA OF THE URINARY BLADDER. IRANIAN JOURNAL OF PATHOLOGY (IJP). 2006 [cited 2021October25];1(1):17-20. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=88893



IEEE: Copy

JALALI NADOUSHAN, M., GHORBANIAN, A., TAHERI, T., 2006. RELATIONSHIP BETWEEN GRADE AND MDM2 ONCOPROTEIN OVEREXPRESSION IN TRANSITIONAL CELL CARCINOMA OF THE URINARY BLADDER. IRANIAN JOURNAL OF PATHOLOGY (IJP), [online] 1(1), pp.17-20. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=88893.



 
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