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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   DECEMBER- JANUARY 2004-2005 , Volume 9 , Number 5 (41); Page(s) 281 To 287.
 
Paper: 

EFFECT OF OMEGA-3 FATTY ACIDS ON INFLAMMATORY MEDIATORS, INSULIN SENSIVITY AND METABOLIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES

 
 
Author(s):  RASTMANESH R., TALEBAN F.A., KIMIAGAR SEYED MASOUD, MEHRABI YAD ELAH
 
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Abstract: 

Background: Type 2 diabetes mellitus may represent a disease of the innate immune system responsible for an ongoing cytokine-mediated acute phase response and fish oil may suppress inflammatory mediator. The ability of omega-3 fatty acids from fish oil to suppress inflammatory mediators and and its consequent effect on glycemia, serum lipids, blood pressure and insulin sensivity was studied in a clinical trial on patients with type 2 diabetes mellitus.
Materials and methods: A total of 26 (10 male and 16 female) were given 3000 mg omega-3 fatty acids, daily, for 8 weeks. The serum level of inflammatory determinates and biochemical ultrasensors were measured by kits, and aquestionnair based on body measurement (anthropometric indexes), medical data was completed.
Results: All 26 cases (10 male, 16 female) full filled the study. mean age, acquiring DM, body mass index were 52.7 9.2 years (1SD), 9 6.0 years, and 27.32 2.9 years respectively. The results of this study showed there were no significant differences in fasting blood glucose and insulin at baseline, week 4 and week 8 after supplementation despite a significant decrease in serum sialic acid triglycerides, cholesterol and blood pressure were decreased.
Conclusion: A moderate dose of omega-3 fatty acids did not lead to deleterious effects on glycemia control in patients with type 2 diabetes mellitus, with preserved beneficial capacities.

 
Keyword(s): TYPE 2 DIABETES MELLITUS, OMEGA-3 FATTY ACIDS, METABOLIC CONTROL, CYTOKINE, ACUTE PHASE PROTEINS
 
References: 
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