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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PEDIATRICS   OCTOBER 2019 , Volume 7 , Number 10 (70); Page(s) 10255 To 10268.
 
Paper: 

Tumor Necrosis Factor alpha, N-terminal Pro Brain Natriuretic Peptide and Interleukin-6 Correlations with Doppler Tissue Imaging findings in Major Thalassemia Patients

 
 
Author(s):  noori noormohammad, teimoori alireza*, Nakhaee Moghadam Maryam, Bagheri Hossein
 
* Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
 
Abstract: 
Background In respect to abnormalities in thalassemia patients and the effects of TNF_α , IL_6, and NT-pro-BNP on echocardiography findings the study aimed to investigate TNF_α , NT-pro-BNP and IL_6 correlations with Doppler tissue imaging findings in major thalassemia. Materials and Methods: This case-control study was performed on 112 healthy children and 112 patients with thalassemia in Ali Asghar hospital, Zahedan, Iran, in 2017. Healthy children were selected from those that referred to the pediatric clinics for routine check-up. Fasting blood samples were taken to measure TNF-α , NT-pro-BNP and IL_6 serums. Those thalassemia patients who had regular transfusions of hemoglobin higher than 10 g/dl and 48-72 h after packed red blood cell transfusion and those who were asymptomatic were entered to the study. Participants underwent echocardiography by pediatric cardiologist in Doppler method. Results: NT-pro-BNP, TNF_α and IL_6 were lower in controls (P<0. 001). Height, weight and BMI were higher in controls (P<0. 001). Right ET, left ET, IVSD, PWD, PWS, EF, FS, left ET', left ICT', left IRT', right ET', right IRT', right S', right Peak A', VE', VA', left and right MPI', LVMI were different in case and control (P<0. 05). Right Peak A (P=0. 049), PWD (P=0. 032), Left MPI' (P=0. 02) and LVMI (P=0. 005) were correlated with IL_6. IVSD (P=0. 01), LVDS (P=0. 01), EF and FS (P<0. 001), left ET' (P=0. 02), left ICT' (P<0. 001), right ET' (P=0. 001), right S' (P=0. 002), left MPI’ (P<0. 010) were correlated with NT-pro-BNP. Conclusion NT-pro-BNP, TNF_α , IL_6 were higher in thalassemia patients and NT-pro-BNP was correlated with some of the echocardiography findings. This suggests that NT-pro-BNP would be the best biomarker for evaluation of cardiac functions in thalassemia patients.
 
Keyword(s): Children,Tumor necrosis factor-α,NT-pro-BNP,Interleukin-6,Thalassemia
 
 
References: 
 
Citations: 
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APA: Copy

NOORI, N., & TEIMOORI, A., & Nakhaee Moghadam, M., & BAGHERI, H. (2019). Tumor Necrosis Factor alpha, N-terminal Pro Brain Natriuretic Peptide and Interleukin-6 Correlations with Doppler Tissue Imaging findings in Major Thalassemia Patients. INTERNATIONAL JOURNAL OF PEDIATRICS, 7(10 (70)), 10255-10268. https://www.sid.ir/en/journal/ViewPaper.aspx?id=783475



Vancouver: Copy

NOORI NOORMOHAMMAD, TEIMOORI ALIREZA, Nakhaee Moghadam Maryam, BAGHERI HOSSEIN. Tumor Necrosis Factor alpha, N-terminal Pro Brain Natriuretic Peptide and Interleukin-6 Correlations with Doppler Tissue Imaging findings in Major Thalassemia Patients. INTERNATIONAL JOURNAL OF PEDIATRICS. 2019 [cited 2021September28];7(10 (70)):10255-10268. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=783475



IEEE: Copy

NOORI, N., TEIMOORI, A., Nakhaee Moghadam, M., BAGHERI, H., 2019. Tumor Necrosis Factor alpha, N-terminal Pro Brain Natriuretic Peptide and Interleukin-6 Correlations with Doppler Tissue Imaging findings in Major Thalassemia Patients. INTERNATIONAL JOURNAL OF PEDIATRICS, [online] 7(10 (70)), pp.10255-10268. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=783475.



 
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