| Abstract:
Background: The hepatotoxic effect of 5-fluorouracil (5-FU) can deprive cancer patients of its maximum therapeutic benefits. Selenium (Se) is a trace element with potential benefits in some animal models of diseases. Objectives: This study assessed the ability of Se to nullify the hepatotoxic effect of 5-FU in albino rats. Methods: In this study, 40 adult male albino rats were grouped into A to D (each 5 rats). Rats in group A (control) were treated intraperitoneally (IP) with normal saline (0. 2 mL) daily for 5 days. Rats in groups B1 to B3 were treated IP with Se (0. 125, 0. 25, and 0. 50 mg/kg) daily for 5 days, respectively. Rats in group C were treated IP with 5-FU (20 mg/kg) daily for 5 days. Rats in groups D1to D3 were treated IP with Se with 0. 125, 0. 25, and 0. 50 mg/kg before treatment with 5-FU (20 mg/kg) daily for 5 days, respectively. After treatment, the rats were euthanized, and their blood samples were collected and evaluated for serum liver function. Liver samples were evaluated for biochemical and histological parameters. Results: Liver and serum aminotransferases, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, total bilirubin, and conjugated bilirubin levels were significantly (P<0. 001) high in 5-FU-treated rats in comparison to the control group. Liver glutathione peroxidase, superoxide dismutase (SOD), catalase, and glutathione levels were significantly (P<0. 001) low whereas the malondialdehyde level was significantly (P<0. 001) high in 5-FU-treated rats compared with the control group. Moreover, hepatocyte necrosis was observed in 5-FU-treated rats. Conclusion: Nonetheless, 5-FU-induced hepatotoxicity was significantly nullified in rats supplemented with Se (0. 125 mg/kg, P<0. 05; 0. 25 mg/kg, P<0. 01, and 0. 5 mg/kg, P<0. 001) in a dose-dependent fashion in comparison to 5-FU-treated rats. Thus, Se may have a clinical benefit in 5-FU-induced hepatotoxicity.
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APA: CopyADIKWU, E., & Ebinyo, N. (2020). Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 6(3), 197-204. https://www.sid.ir/en/journal/ViewPaper.aspx?id=782529 Vancouver: CopyADIKWU ELIAS, Ebinyo Nelson Clemente. Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity. PHARMACEUTICAL AND BIOMEDICAL RESEARCH. 2020 [cited 2022June26];6(3):197-204. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=782529 IEEE: CopyADIKWU, E., Ebinyo, N., 2020. Selenium Safeguards the Liver Against 5-Fluorouracil Induced Toxicity. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, [online] 6(3), pp.197-204. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=782529.
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