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Paper Information

Journal:   JOURNAL OF IRANIAN ANATOMICAL SCIENCES   SPRING 2004 , Volume 2 , Number 1; Page(s) 29 To 35.
 
Paper: 

EFFECT OF SPECIFIC LESION OF NON SEROTONERGIC PATHWAY ON NEURONS OF NUCLEUS RAPHE MAGNUS MORPHOLOGY IN RAT

 
 
Author(s):  JOGHATAEI M.T.*, BEHZADI J., NIKBAKHT F.
 
* ANATOMY DEPARTMENT, IRAN MEDICAL SCIENCES UNIVERSITY, TEHRAN, IRAN
 
Abstract: 
Purpose: The nucleus raphe magnus (NRM) is a medullary nucleus containing serotonergic and non serotonergic neurons, both of which densely project to spinal cord. The goal of this study was to determine the role of these non serotonergic neurons in pain perception and their cytological changes after the specific lesion of bulbo-spinal serotonergic pathway.Materials and Methods: Male rats were intrathecally administered 5,6 Dihydroxytryptamine (5,6 DHT). Then animals were perfused 5, 14 and 30 days after the injection of neurotoxin or vehicle. Serial microtom sections (5-8 microns) were Nissl Stained, and the cytological changes of neurons were evaluated by light microscope.Results: The results revealed that the number of all three types of NRM neurons was significantly reduced following the intrathecal injection of 5, 6 DHT. The reduction was not recovered within one month, although; the pain perception returned to normal level. In addition, a significant enlargement (increase in long axis) was also observed in NRM neurons after the chemical lesions of descending 5-HT pathways (p<0.001).Conclusion: It is concluded that no evident recovery will be seen in serotonergic pathways after their select in destruction, although the pain perception becomes normal after one month. Normal threshold of pain indicates a probable function adaptation of other transmission systems, which compensates for the loss of serotonergic neurons.
 
Keyword(s): RAPHE MAGUUS, NEUROTOXIN (5, 6 DHT), CYTOLOGIC CHANGES
 
 
References: 
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Citations: 
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APA: Copy

JOGHATAEI, M., & BEHZADI, J., & NIKBAKHT, F. (2004). EFFECT OF SPECIFIC LESION OF NON SEROTONERGIC PATHWAY ON NEURONS OF NUCLEUS RAPHE MAGNUS MORPHOLOGY IN RAT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 2(1), 29-35. https://www.sid.ir/en/journal/ViewPaper.aspx?id=74041



Vancouver: Copy

JOGHATAEI M.T., BEHZADI J., NIKBAKHT F.. EFFECT OF SPECIFIC LESION OF NON SEROTONERGIC PATHWAY ON NEURONS OF NUCLEUS RAPHE MAGNUS MORPHOLOGY IN RAT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES. 2004 [cited 2021December08];2(1):29-35. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=74041



IEEE: Copy

JOGHATAEI, M., BEHZADI, J., NIKBAKHT, F., 2004. EFFECT OF SPECIFIC LESION OF NON SEROTONERGIC PATHWAY ON NEURONS OF NUCLEUS RAPHE MAGNUS MORPHOLOGY IN RAT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, [online] 2(1), pp.29-35. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=74041.



 
 
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