SID.ir New Version

Paper Information

Journal:   FEYZ   AUGUST-SEPTEMBER 2018 , Volume 22 , Number 3 ; Page(s) 258 To 266.
 
Paper: 

The Effect Of Cyclooxygenase-2 Inhibition On Pentylenetetrazole-Induced Seizure Threshold In Mice

 
 
Author(s):  Mesdaghinia A., Khazaee P., Heydari A.*
 
* Physiology Research Center, Kashan, University of Medical Sciences, Kashan, I. R. Iran
 
Abstract: 
Background: Previous studies have shown the protective effect of cyclooxygenase (COX) enzyme in development of convulsions. However, involvement of COX-2 in the pathogenesis of epilepsy is not yet well-known. The present study was designed to investigate the effect of celecoxib and nimesulide (selective COX-2 inhibitors) on pentylenetetrazole (PTZ)-induced clonic seizure threshold in mice. Materials and Methods: In this study, white male mice were randomly divided into 13 groups including control groups, solvent (Tween 80) and eleven experimental groups which received celecoxib (2. 5, 5 and 10 mg/kg), nimesulide (2. 5, 5 and 10 mg/kg), diazepam (0. 1, 0. 5 and 5 mg/kg), and combination of non-effective dose of diazepam with celecoxib or nimesulide. Pentylenetetrazol-induced clonic seizure threshold was assessed in all groups. Results: Nimesulide (2. 5 and 5 mg/kg), celecoxib (2. 5 and 5 mg/kg), and diazepam (0. 5 and 5 mg/kg) significantly increased the PTZ-induced seizure threshold compared with the solvent group (P<0. 05). Also, only combination of sub-effective dose of diazepam (0. 1 mg/kg) with celecoxib (2. 5 mg/kg) showed a significant protective effect against PTZinduced seizure threshold (P<0. 01). Conclusion: Findings of the current study show the possible role of COX-2 isoenzyme in the pathophysiology of epilepsy. It is possible that some COX-2 inhibitors such as celecoxib act through GABAergic neurons and reduce excitability by increasing GABA release. Also, the difference between the effects of celecoxib and nimesulide can be attributed to the effect of these two compounds on COX-1 and COX-2 expression.
 
Keyword(s): Seizure,Pentylenetetrazole,Cyclooxygenase-2,GABA
 
 
International related papers: 
  • No item.
 
Most related Highly related Moderately related Least related
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
 
+ Click to Cite.
APA: Copy

MESDAGHINIA, A., & Khazaee, P., & HEYDARI, A. (2018). The effect of cyclooxygenase-2 inhibition on pentylenetetrazole-induced seizure threshold in mice. FEYZ, 22(3 ), 258-266. https://www.sid.ir/en/journal/ViewPaper.aspx?id=702533



Vancouver: Copy

MESDAGHINIA A., Khazaee P., HEYDARI A.. The effect of cyclooxygenase-2 inhibition on pentylenetetrazole-induced seizure threshold in mice. FEYZ. 2018 [cited 2022May21];22(3 ):258-266. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=702533



IEEE: Copy

MESDAGHINIA, A., Khazaee, P., HEYDARI, A., 2018. The effect of cyclooxygenase-2 inhibition on pentylenetetrazole-induced seizure threshold in mice. FEYZ, [online] 22(3 ), pp.258-266. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=702533.



 
 
Persian Abstract Yearly Visit 49
 
 
Latest on Blog
Enter SID Blog