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Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   july 2018 , Volume 23 , Number 7; Page(s) 0 To 0.
 
Paper: 

The relationship between L‑ leucine‑ 7‑ amido ‑ 4‑ methyl coumarin 1 gene polymorphism and susceptibility to the chronic hepatitis B virus infection in an Iranian population

 
 
Author(s):  MOUDI BITA, HEIDARI ZAHRA*, MAHMOUDZADEH SAGHEB HAMIDREZA, FARROKH PARISA
 
* Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
 
Abstract: 
Background: Lamnin has important effects on human immunity system. The current study aimed to assess the role of L‑ leucine‑ 7‑ amido‑ 4‑ methyl coumarin 1 gene polymorphisms on hepatitis B virus (HBV) susceptibility. Materials and Methods: The rs20558, rs20563, rs10911193, rs10911251, and rs1413390 polymorphisms were analyzed using polymerase chain reaction (PCR) and PCR‑ reaction– restriction fragment‑ length polymorphism and amplification‑ refractory mutation system‑ PCR using three different groups including chronic HBV‑ infected patients, HBV patients who were resolved their infection spontaneously and healthy volunteers. Laminin concentrations were also measured in the blood of these individuals. Results: People with rs20558C, rs20563G, and rs10911193T alleles have an increased risk of HBV infection. Moreover, we found that CGTAT haplotype was more frequent in chronically infected people who could affect the mechanism of disease. Furthermore, there was a significant relationship between laminin concentration and rs20558, rs20563, and rs10911193 genotypes in patients. Conclusion: According to the statistical analysis, rs20558, rs20563, rs10911193 polymorphisms probably, related to the chronic HBV infection. In addition, no association of the rs10911251, rs1413390 single nucleotide polymorphisms with the disease was found.
 
Keyword(s): Hepatitis B virus,laminin,single nucleotide polymorphism
 
 
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APA: Copy

MOUDI, B., & HEIDARI, Z., & MAHMOUDZADEH SAGHEB, H., & FARROKH, P. (2018). The relationship between L‑ leucine‑ 7‑ amido ‑ 4‑ methyl coumarin 1 gene polymorphism and susceptibility to the chronic hepatitis B virus infection in an Iranian population. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 23(7), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=692457



Vancouver: Copy

MOUDI BITA, HEIDARI ZAHRA, MAHMOUDZADEH SAGHEB HAMIDREZA, FARROKH PARISA. The relationship between L‑ leucine‑ 7‑ amido ‑ 4‑ methyl coumarin 1 gene polymorphism and susceptibility to the chronic hepatitis B virus infection in an Iranian population. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS). 2018 [cited 2021September24];23(7):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=692457



IEEE: Copy

MOUDI, B., HEIDARI, Z., MAHMOUDZADEH SAGHEB, H., FARROKH, P., 2018. The relationship between L‑ leucine‑ 7‑ amido ‑ 4‑ methyl coumarin 1 gene polymorphism and susceptibility to the chronic hepatitis B virus infection in an Iranian population. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), [online] 23(7), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=692457.



 
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