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Paper Information

Journal:   AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)   April-June 2019 , Volume 11 , Number 2; Page(s) 192 To 201.
 
Paper: 

Antibiotic Susceptibility Patterns And Prevalence Of Some Extended Spectrum Beta-Lactamases Genes In Gram-Negative Bacteria Isolated From Patients Infected With Urinary Tract Infections In Al-Najaf City, Iraq

 
 
Author(s):  Majeed Heba Takleef, Jaloob Aljanaby Ahmed Abduljabbar*
 
* Department of Microbiology, Faculty of Science, University of Kufa, Kufa, Iraq
 
Abstract: 
Background: Urinary Tract Infection (UTI) in patients with Chronic Kidney Disease (CKD) caused by multi-drug resistance and Extended Spectrum Beta Lactamase (ESBL)-producing gram-negative bacteria has been increased in different countries. The aim of the present study was to detect the antibiotic susceptibility patterns and the distribution of Bla-TEM, Bla-SHV and Bla-CTX-M genes in gram-negative bacte-ria isolated from outpatients infected with UTI, with and without CKD in Al-Najaf city, Iraq. Methods: A total of 120 non-duplicate urine samples were collected from outpatients (37 male and 83 female) infected with UTI in Al-Najaf city, Iraq; 60 samples from pa-tients Without Kidney Disease (WKD) and 60 samples from patients with CKD. The antibiotic susceptibility testing was done according to Kirby-Bauer method. PCR technique was performed to investigate the prevalence of Bla-TEM, Bla-SHV and Bla-CTX-M genes. Results: A total of 126 different gram-negative bacterial strains were isolated. Esche-richia coli (E. coli) was the most prevalent bacterium (49 isolates) followed by Idebsiella pneumonia (K. pneumonia) (35 isolates), Pseudomonas aeruginosa (P. ae-ruginosa) (18 isolates), Citrobacter freundii (C. freundii) (12 isolates), Enterobocter aer-ogenes (E. aerogenes) (8 isolates) and Proteus mirabilis (P. mirabilis) (4 isolates). All bacterial isolates from UTI patients with CKD were resistant to antibiotics and carried Bla-TEM, Bla-SHV and Bla-CTX-M genes more than isolates from UTI patients with WKD. Conclusion: This study demonstrated that all bacterial isolates from UTI patients with CKD were more virulent than isolates from UTI patients with WKD.
Keyword(s): Iraq,Chronic kidney disease,SHV,TEM,Urinary tract infections
 
 
 
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APA: Copy

Majeed, H., & Jaloob Aljanaby, A. (2019). Antibiotic Susceptibility Patterns and Prevalence of Some Extended Spectrum Beta-Lactamases Genes in Gram-Negative Bacteria Isolated from Patients Infected with Urinary Tract Infections in Al-Najaf City, Iraq. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 11(2), 192-201. https://www.sid.ir/en/journal/ViewPaper.aspx?id=684780



Vancouver: Copy

Majeed Heba Takleef, Jaloob Aljanaby Ahmed Abduljabbar. Antibiotic Susceptibility Patterns and Prevalence of Some Extended Spectrum Beta-Lactamases Genes in Gram-Negative Bacteria Isolated from Patients Infected with Urinary Tract Infections in Al-Najaf City, Iraq. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB). 2019 [cited 2022January18];11(2):192-201. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=684780



IEEE: Copy

Majeed, H., Jaloob Aljanaby, A., 2019. Antibiotic Susceptibility Patterns and Prevalence of Some Extended Spectrum Beta-Lactamases Genes in Gram-Negative Bacteria Isolated from Patients Infected with Urinary Tract Infections in Al-Najaf City, Iraq. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), [online] 11(2), pp.192-201. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=684780.



 
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