Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   may 2018 , Volume 16 , Number 5; Page(s) 299 To 304.
 
Paper: 

Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT

 
 
Author(s):  AREFI SOHEILA, FAZELI ELHAM, Esfahani Manijeh, BORHANI NASIM, YAMINI NAZILA, HOSSEINI AHMAD, FARIFTEH FATTANEH*
 
* Genetics and In Vitro Assisted Reproductive (GIVAR) Center, Erfan Hospital, Tehran, Iran/Cellular and Molecular Biology Research Center, Shahid,Post code: 1928884349 Beheshti University of Medical Sciences, Tehran, Iran
 
Abstract: 
Background: Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium. Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures. Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures. All patients were stimulated with standard long protocol. All embryos were transferred on day five in blastocyst stage in both groups. The treated group received 300 μ g (0. 5 ml) recombinant human G-CSF subcutaneously which was injected 30 min before blastocyst embryo transfer. Results: There was not statistically significant differences in abortion rate in G-CSF and control group (p=0. 09). G-CSF treated group showed higher clinical pregnancy rate in comparison with control group (56. 2% vs. 40. 0%) but it was not statistically significant (p=0. 09). Although live birth rate in G-CSF group was higher than control group (53. 1% vs. 35. 0%) but there wasn’ t statistically significant difference in the overall live birth rate between the two groups (p=0. 10). G-CSF group had a twin pregnancies while in control group there was no twin pregnancy. Conclusion: Our result demonstrates the possibility that pregnancy outcome is better in women with repeated unexplained In vitro fertilization failure who are treated with G-CSF.
 
Keyword(s): Granulocyte colony-stimulating factor,Embryo implantation,Pregnancy rates,Assisted reproductive technology,Randomized controlled trial
 
 
References: 
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

AREFI, S., & FAZELI, E., & Esfahani, M., & BORHANI, N., & YAMINI, N., & HOSSEINI, A., & FARIFTEH, F. (2018). Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(5), 299-304. https://www.sid.ir/en/journal/ViewPaper.aspx?id=668828



Vancouver: Copy

AREFI SOHEILA, FAZELI ELHAM, Esfahani Manijeh, BORHANI NASIM, YAMINI NAZILA, HOSSEINI AHMAD, FARIFTEH FATTANEH. Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE). 2018 [cited 2021July29];16(5):299-304. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=668828



IEEE: Copy

AREFI, S., FAZELI, E., Esfahani, M., BORHANI, N., YAMINI, N., HOSSEINI, A., FARIFTEH, F., 2018. Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), [online] 16(5), pp.299-304. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=668828.



 
  pdf-File
Yearly Visit 0
 
 
Latest on Blog
Enter SID Blog