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Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   MARCH-APRIL 2018 , Volume 25 , Number 166 ; Page(s) 58 To 66.
 
Paper: 

The Effects Of Cytotoxic Thyroid Hormone T4 On Proliferation Of Brain Glioblastoma Cells (A172) In Vitro

 
 
Author(s):  Ahmadi Rahim, Sagharjoghi Farahani Morteza*, Khodadadi Babak
 
* Young Researchers and Elite Club, Islamshahr Azad University, Islamshahr, Iran
 
Abstract: 
Background: Studies showed thyroid hormones influence proliferation of cancer cells. The main aim of this study was to investigate the effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in cell culture. Methods: In this laboratory experimental study, A172 cells were randomly divided into control group and groups exposed to doses 0. 1, 0. 5, 1, 5, 10, 20, 40, 50 Lambda (λ ) of thyroid hormone T4. The toxic effect of hormones was measured using MTT assay method. The data were statistically analyzed between groups using ANOVA. Results: The result demonstrated that highest toxicity of thyroid hormone T4 on glioblastoma cancer cells A172 was in 1 lambda (λ ) dosage and low toxicity in 0. 1 and 40 lambdas (λ ) dosages. Conclusion: Toxicity of Glioblastoma cancer cells is either hormone dependent or hormone independent.
 
Keyword(s): Cytotoxic,Thyroid Hormones T4,A172 Cells
 
 
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APA: Copy

AHMADI, R., & Sagharjoghi Farahani, M., & Khodadadi, B. (2018). The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(166 ), 58-66. https://www.sid.ir/en/journal/ViewPaper.aspx?id=655992



Vancouver: Copy

AHMADI RAHIM, Sagharjoghi Farahani Morteza, Khodadadi Babak. The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES). 2018 [cited 2022May23];25(166 ):58-66. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=655992



IEEE: Copy

AHMADI, R., Sagharjoghi Farahani, M., Khodadadi, B., 2018. The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), [online] 25(166 ), pp.58-66. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=655992.



 
 
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