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Paper Information

Journal:   IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)   2017 , Volume 20 , Number 5 ; Page(s) 437 To 448.
 
Paper: 

Study of Association Between Polymorphism Alpha7 Neuronal Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) with the Development of Schizophrenia in Iranian Population

 
 
Author(s):  Haghighat sh., Zahmatkesh Roodsari r.*, Ranjbar R.
 
* Department of Genetics, School of Biological Sciences, Tonekabon Azad University, Tonekabon, Iran
 
Abstract: 
Background: SCZ (Schizophrenia) is common psychiatric and mentally disorder which display common genetic vulnerability. The α 7 neuronal nicotinic receptor gene (CHRNA7) is located on chromosome 15q13-q14. There are many single nucleotide polymorphisms (SNPs) in exons, introns and promoter sites inside the CHRNA7 gene. The aim of this research was study of polymorphism CHRNA7 with the development of schizophrenia in Iranian population. Materials and Methods: This case-control study included 100 patients with schizophrenia and 100 normal peoples as a control group were investigated. Genomic DNA was extracted from blood samples. Genotypes were detected by using a PCR-RFLP method. Statistical analysis was done by using the SPSS software version 20. Results: Frequency of CC, TC, TT genotypes in patients group were 18%, 42%, 40% and in normal groups were 14%, 45%, 41%, respectively. Statistical analysis were showed that in the total sample (male and female), there was no significant association between CHRNA7 gene polymorphism with schizophrenia disease. Conclusion: The presence of the T allele in CHRNA7 gene at rs904942 is not considered as a risk factor for schizophrenia. Therefore, further genetic studies with more SNPs and larger samples covering various populations, are needed.
 
Keyword(s): Schizophrenia,polymorphism,CHRNA7,PCR-RFLP
 
 
References: 
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Cite:
APA: Copy

HAGHIGHAT, S., & Zahmatkesh Roodsari, r., & RANJBAR, R. (2017). Study of Association Between Polymorphism Alpha7 Neuronal Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) with the Development of Schizophrenia in Iranian Population. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 20(5 ), 437-448. https://www.sid.ir/en/journal/ViewPaper.aspx?id=653509



Vancouver: Copy

HAGHIGHAT SH., Zahmatkesh Roodsari r., RANJBAR R.. Study of Association Between Polymorphism Alpha7 Neuronal Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) with the Development of Schizophrenia in Iranian Population. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ). 2017 [cited 2021April20];20(5 ):437-448. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=653509



IEEE: Copy

HAGHIGHAT, S., Zahmatkesh Roodsari, r., RANJBAR, R., 2017. Study of Association Between Polymorphism Alpha7 Neuronal Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) with the Development of Schizophrenia in Iranian Population. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), [online] 20(5 ), pp.437-448. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=653509.



 
 
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