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Paper Information

Journal:   MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES   OCTOBER-NOVEMBER 2017 , Volume 60 , Number 4 ; Page(s) 597 To 609.
 
Paper: 

RELATION BETWEEN AMH LEVEL AND OVARIAN RESERVE IN INFERTILE WOMEN CANDIDATE FOR ASSISTED REPRODUCTIVE TREATMENT

 
 
Author(s):  MIRZAMORADI MASSOMEH, SARFJOO FATEMEH SADAT, BAKHTIARI MAHMOOD, MAHMOODI MEHRI, HEYDAR ZAHRA*
 
* SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, MAHDIEH HOSPITAL, TEHRAN, IRAN
 
Abstract: 
Introduction: The purpose of this study was to predict the poor and excessive ovarian response using anti-Mü llerian hormone (AMH) levels following a long agonist protocol in IVF candidates. MaterialS and Methods: Through a prospective cohort study, the type of relationship and appropriate scale for AMH were determined using the fractional polynomial regression. To determine the effect of AMH on the outcomes of ovarian stimulation and different ovarian responses, the multi-nominal and negative binomial regression models were fitted using backward stepwise method. The ovarian response of studIED subject who entered a standard long-term treatment cycle with GnRH agonist was evaluated using prediction model, separately and in combined models with (ROC) curves. Results: The use of standard long-term treatments with GnRH agonist led to positive pregnancy test results in 30% of treated patients. With each unit increase in the log of AMH, the odds ratio of having poor response compared to normal response decreases by 64% (OR 0. 36, 95% CI 0. 19-0. 68. The optimal cut-off points of AMH for predicting excessive and poor ovarian responses were 3. 4 and 1. 2 ng/ml, respectively, with area under curves of 0. 69 (0. 60-0. 77) and 0. 76 (0. 66-0. 86), respectively. Conclusion: By considering the age of the patient undergoing infertility treatment as a variable affecting ovulation, use of AMH levels showed to be a good test to discriminate between different ovarian responses.
 
Keyword(s): AMH, OVARIAN RESERVE, OVARIAN RESPONSE
 
References: 
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