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Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   JUNE 2018 , Volume 76 , Number 3 ; Page(s) 211 To 215.
 
Paper: 

The Function Of Factors And Exacerbation Of Polycystic Ovary Syndrome: Brief Report

 
 
Author(s):  Mousazadeh Sepideh, Rahimi Atefeh, Gosili Roya*, Ghaheri Azadeh, Khaksar Fateme
 
* CAUCASUS INFERTILITY TREATMENT CENTER, NEXT TO SHAHID GHANDI TELECOMMUNICATIONS CENTER, SHOHADA SQ. (BOUALI HOSPITAL), DADGOSTARI ST., ARDABIL, IRAN, POST CODE: 5613614491
 
Abstract: 
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder and one of themain reasons of infertility in women. PCOS causes many symptoms in women, one of themost important of them is ovulation failure. It affects the women at the age of fertility. Many factors are detected to exacerbate PCOS including insulin, anti-Mullerian hormone, obesity and androgen. The aim of this study was to evaluate endocrine and metabolic factorsand its relation with obesity in patients with polycystic ovary syndrome in exacerbationof disease. Methods: This cross-sectional study was carried out at the Caucasus Infertility TreatmentCenter of Ardabil from July 2015 to March 2016 and on 321 patients with polycystic ovarysyndrome. Blood samples were investigated to measure serum levels of fasting insulin, dehydroepiandrosterone sulfate (DHEAS), 17OHP, fasting blood sugar, sex hormonebinding globulin (SHBG), anti-Mullerian hormone, vitamin D, total testosterone, freetestosterone, prolactin, FSH, LH and TSH. Also, body mass index (BMI), duration ofinfertility and age were measured. BMI was evaluated to measure the obesity of patients. Results: We were able to demonstrate significantly high level of total testosterone andfasting insulin in PCOS women by having weight gain (P< 0. 05). Response to drug wassignificantly increased with reduced weight of these patients (P= 0. 02). The level offasting blood sugar (P= 0. 01) and anti-Mullerian hormone (P< 0. 05) were increasedsignificantly with access in PCOS. On the other hand, our data showed that duration ofinfertility was increased by growing the age of patients (P< 0. 05). Conclusion: Insulin resistance, obesity, hyperandrogenism and metabolic syndrome arevery important factors in pathogenesis of PCOS. These factors could affect the fertilityof women by effecting the reproductive processes. Therefore, it is better in the patientswho are older, treatment strategies further underline on reduce these factors (insulinresistance, obesity and hyperandrogenism) to prevent disease progression and increaseduration of infertility.
 
Keyword(s): BODY MASS INDEX, INSULIN, POLYCYSTIC OVARY SYNDROME, TESTOSTERONE
 
 
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APA: Copy

MOUSAZADEH, S., & RAHIMI, A., & GOSILI, R., & GHAHERI, A., & KHAKSAR, F. (2018). THE FUNCTION OF FACTORS AND EXACERBATION OF POLYCYSTIC OVARY SYNDROME: BRIEF REPORT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(3 ), 211-215. https://www.sid.ir/en/journal/ViewPaper.aspx?id=609208



Vancouver: Copy

MOUSAZADEH SEPIDEH, RAHIMI ATEFEH, GOSILI ROYA, GHAHERI AZADEH, KHAKSAR FATEME. THE FUNCTION OF FACTORS AND EXACERBATION OF POLYCYSTIC OVARY SYNDROME: BRIEF REPORT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ). 2018 [cited 2022August13];76(3 ):211-215. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=609208



IEEE: Copy

MOUSAZADEH, S., RAHIMI, A., GOSILI, R., GHAHERI, A., KHAKSAR, F., 2018. THE FUNCTION OF FACTORS AND EXACERBATION OF POLYCYSTIC OVARY SYNDROME: BRIEF REPORT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), [online] 76(3 ), pp.211-215. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=609208.
 
 
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