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Paper Information

Journal:   NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM   WINTER 2018 , Volume 6 , Number 1 #R00249; Page(s) 1 To 9.
 
Paper: 

EFFECT OF CURCUMIN ON HIPPOCAMPAL LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR AND SERUM LEVELS OF INFLAMMATORY CYTOKINES IN RAT MODEL FOR ALZHEIMER’S DISEASE

 
 
Author(s):  SADOUGHI SEYED DAMOON*, KHAYATZADEH JINA
 
* YOUNG RESEARCHERS AND ELITE CLUB, MASHHAD BRANCH, ISLAMIC AZAD UNIVERSITY, MASHHAD, IRAN
 
Abstract: 

Introduction: Alzheimer’s disease (AD) is a progressive neurodegenerative disease of the central nervous system. Neuronal injury and oxidative stress in AD increases the level of inflammatory cytokines. Curcumin has antioxidant and neuroprotective properties. The aim of this study was to determine the effect of curcumin on hippocampal levels of brain-derived neurotrophic factor (BDNF) and serum levels of inflammatory cytokines in an experimental model of AD.
Materials and Methods: 28 male rats divided into 4 groups: Control group (30 days, intraperitoneal injection of DMSO), AD control group (30 days, intraperitoneal injection of DMSO, after induction of AD) and two AD treatment groups with application of 50 and 100 mg/kg of curcumin (30 days, intraperitoneal injection of curcumin, after induction of AD). AD was induced by intraperitoneal injection of 8 mg/kg trimethyltin chloride. At the end of the treatment period, the hippocampal levels of BDNF and serum levels of different cytokines (TNF-
a, IL-1b and IL-6) were measured by ELISA method.
Results: Compared to AD control group, administration of curcumin with dose of 100 mg/kg significantly increased the hippocampal levels of BDNF (P=0.002) and decreased the serum levels of TNF-
a, IL-1b and IL-6 (P=0.001).
Conclusion: Administration of curcumin may decrease the serum levels of inflammatory cytokines in AD, possibly via enhancement of the hippocampal levels of BDNF. This study suggests the protective effect of curcumin against neuronal damages and oxidative stress in AD.

 
Keyword(s): CURCUMIN, RATS, BRAIN-DERIVED, NEUROTROPHIC FACTOR
 
References: 
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