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Journal:   IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE)   2017 , Volume 36 , Number 6; Page(s) 57 To 67.
 
Paper: 

A Convenient Base-Mediated Diastereoselective Synthesis Of 2-Oxo-N,4,6 Triarylcyclohex-3-Enecarboxamides Via Claisen-Schmidt Condensation

 
 
Author(s):  Mousavi Seyyed Rasul*
 
* YOUNG RESEARCHERS AND ELITES CLUB, SCIENCE AND RESEARCH BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, I.R. IRAN
 
Abstract: 
Sodium acetate catalyzed the multi-component reaction of acetophenone, aromatic aldehydes, and acetoacetanilide in the water-ethanol mixture (1: 1) at ambient temperature via Claisen-Schmidt condensation results in the formation of highly substituted cyclohexenones in 89–98% yields. The developed ef?cient catalytic approach to the substituted cyclohexenones – the promising compounds for in?ammation and autoimmune diseases therapy and different biomedical applications – is bene?cial from the viewpoint of diversity-oriented large-scale processes and represents facile, ef?cient and environmentally benign synthetic concept for multicomponent reactions strategy. This protocol offers several advantages including high yields, operational simplicity, clean reaction conditions, the minimum pollution of the environment, no need to column chromatography and simple work-up procedure.
 
Keyword(s): KNOEVENAGEL CONDENSATION, MICHAEL REACTION, DIASTEREOSELECTIVE SYNTHESIS, SODIUM ACETATE, 2-OXO-N,4,6-TRIARYLCYCLOHEX-3-ENECARBOXAMIDE
 
 
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APA: Copy

MOUSAVI, S. (2017). A CONVENIENT BASE-MEDIATED DIASTEREOSELECTIVE SYNTHESIS OF 2-OXO-N,4,6 TRIARYLCYCLOHEX-3-ENECARBOXAMIDES VIA CLAISEN-SCHMIDT CONDENSATION. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE), 36(6), 57-67. https://www.sid.ir/en/journal/ViewPaper.aspx?id=582023



Vancouver: Copy

MOUSAVI SEYYED RASUL. A CONVENIENT BASE-MEDIATED DIASTEREOSELECTIVE SYNTHESIS OF 2-OXO-N,4,6 TRIARYLCYCLOHEX-3-ENECARBOXAMIDES VIA CLAISEN-SCHMIDT CONDENSATION. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE). 2017 [cited 2022May20];36(6):57-67. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=582023



IEEE: Copy

MOUSAVI, S., 2017. A CONVENIENT BASE-MEDIATED DIASTEREOSELECTIVE SYNTHESIS OF 2-OXO-N,4,6 TRIARYLCYCLOHEX-3-ENECARBOXAMIDES VIA CLAISEN-SCHMIDT CONDENSATION. IRANIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING (IJCCE), [online] 36(6), pp.57-67. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=582023.



 
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