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Paper Information

Journal:   DANESHVAR MEDICINE   August-September , Volume 10 , Number 46; Page(s) 33 To 38.
 
Paper: 

EFFECT OF ADENOSINE ON CONTRACTILITY, HEART RATE AND CORONARY FLOW OF GUINEA PIG ISOLATED HEART DUE TO NITRIC OXIDE AND PROSTAGLANDINS SYNTHESIS INHIBITION

 
 
Author(s):  KHALILI NAJAFABADI M.*
 
* DEPT. OF PHYSIOLOGY, FACULTY OF MEDICINE, SHAHED UNIVERSITY
 
Abstract: 

It was shown that A1 adenosine receptors on S.A. node and myocardial tissue, respectively are responsible for heart rate decrement and negative dromotropic effects. Also, A2 adenosine receptors activation on coronary endothelium are responsible for coronary vasodilatation. Adenosine receptors activation could produce intermediate molecules such as NO and PGs. This products could have vasodilatory and negative dromoptropic effect. We examined whether the action of adenosine on these mentioned heart parameters do through NO or PGs synthesis.
Our experiment showed that a significant decrement (11.12±3.5) occurred in coronary flow following NO synthesis inhibition due to NLA application, even though no significant changes were shown in heart rate and contractility. Comparative study on the effect of adenosine and adenosine + NLA indicated that probably, a part of adenosine effect on heart rate and contractility parameters are mediated by NO synthesis.
Inhibition of prostaglandins synthesis following indometacine application had no effect on heart parameters. Comparing the effect of adenosine and adenosine +Indo indicated no significant difference. So, it concluded that adenosine could affected the heart parameters in other ways than PGs synthesis.
In addition, our experiments show that a part of coronary vessle dilation and negative dromotropic effect of adenosine are mediated via NO synthesis.

 
Keyword(s): ISOLATED HEART, CONTRACTILITY, HEART RATE, CORONARY, FLOW, NO, PGS
 
References: 
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