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Paper Information

Journal:   PHARMACEUTICAL SCIENCES   Spring-Summer 2003 , Volume - , Number 1; Page(s) 37 To 42.
 
Paper: 

EXTRACTION OF PYOVERDIN FROM P. AERUGINOSA CULTURE AND STUDY ON ITS ANTIBACTERIAL PROPERTIES

 
 
Author(s):  NAZEMIEH H., KERMANSHAHI R.K., AFAGHI A., DELAZAR A., AFSHAR J.
 
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Abstract: 

Pseudomonas aeruginosa, an opportunistic human pathogen, involves in several infections and often in bums, patients with cystic fibrosis and immune-compromised. It produces several siderophores, which play role in the development of bacterial infection. Pyoverd in is formed in iron depletion situation and enhances the iron uptake. In the present study we extracted Pyoverdin from P.aeruginosa (hospital sample) culture media for studding inhibitory effect Pyoverdin Siderophore, produced by Pseudomonas aeruginosa, on some Species of Staphylococcus aureus, Escherichia Coli and Klebsiella pneumonia. Quantity of Pyoverdin was determined by U.V. Spectrophotometry method and then, its antibacterial properties were studied by using solvent-solvent extraction and results were compared with standard antibiotics. These investigation showed that Staphylococcus areus more sensitive to Pyoverd in than the others. Finally we determined that inhibitory activity of Pyoverd in diminishes after 2 month storing at 4°C.

 
Keyword(s): SIDEROPHORES, PYOVERDIN, P.AERUGINOSA
 
References: 
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