Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   PHARMACEUTICAL SCIENCES   Spring-Summer 2003 , Volume - , Number 1; Page(s) 11 To 20.
 
Paper: 

MATHEMATICAL REPRESENTATION OF ELECTROPHORETIC MOBILITY OF PROPRANOLOL IN BINARY SOLVENTS AT DIFFERENT TEMPERATURES IN CAPILLARY ELECTROPHORESIS

 
 
Author(s):  JOUYBAN A.A.GH., CLARK J.
 
* 
 
Abstract: 

In order to optimize the concentration of organic solvent and temperature in method development stage in capillary electrophoresis, the electrophoretic mobility of propranolol in different concentrations of methanol in water-methanol mixtures at 20, 30 and 40°C has been determined. The mobility decreases with an increase in methanol concentration in the mixture, then reaches a minimum value and increases with further increase in methanol concentration at each temperature. The mobility increases with increased temperature and a linear relationship between the logarithm of mobility and reversed absolute temperature has been observed. The obtained experimental data have been fitted to a proposed model calculating the logarithm of mobility with respect to the concentration of solvents in binary solvents and temperatures. The model is:
1nµ m,T= ƒc 1n µ c,T+J1c ƒW /T) + J2c2 ƒw/T)
Where µm,T, µc,T and µw,T denote the electrophoretic mobility in mixed solvent, pure cosolvent and water at temperature T, respectively, fe and fware the volume fractions of the cosolvent and water in the mixture and J1-J2 are the model constants. The calculated percentage errors for different numerical analyses are between 4.8 to 6.4 percent. These errors lie within experimental relative standard deviations. The proposed model could help the analyst to speed up the method development in capillary electrophoresis.

 
Keyword(s): ELECTROPHORETIC MOBILITY, CAPILLARY ELECTROPHORESIS, MIXED SOLVENT, MODELLING, ALPRENOLOL
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

JOUYBAN, A., & CLARK, J. (2003). MATHEMATICAL REPRESENTATION OF ELECTROPHORETIC MOBILITY OF PROPRANOLOL IN BINARY SOLVENTS AT DIFFERENT TEMPERATURES IN CAPILLARY ELECTROPHORESIS . PHARMACEUTICAL SCIENCES, -(1), 11-20. https://www.sid.ir/en/journal/ViewPaper.aspx?id=57365



Vancouver: Copy

JOUYBAN A.A.GH., CLARK J.. MATHEMATICAL REPRESENTATION OF ELECTROPHORETIC MOBILITY OF PROPRANOLOL IN BINARY SOLVENTS AT DIFFERENT TEMPERATURES IN CAPILLARY ELECTROPHORESIS . PHARMACEUTICAL SCIENCES. 2003 [cited 2021July28];-(1):11-20. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=57365



IEEE: Copy

JOUYBAN, A., CLARK, J., 2003. MATHEMATICAL REPRESENTATION OF ELECTROPHORETIC MOBILITY OF PROPRANOLOL IN BINARY SOLVENTS AT DIFFERENT TEMPERATURES IN CAPILLARY ELECTROPHORESIS . PHARMACEUTICAL SCIENCES, [online] -(1), pp.11-20. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=57365.



 
 
Persian Abstract Yearly Visit 31
 
 
Latest on Blog
Enter SID Blog