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Paper Information

Journal:   DANESHVAR MEDICINE   JULY 2017 , Volume 24 , Number 129; Page(s) 65 To 74.
 
Paper: 

THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT

 
 
Author(s):  SHAYESTEH RAD FATEMEH, FARZANEGI PARVIN*, HABIBIAN MASOUMEH, ALINEJAD HADI
 
* DEPARTMENT OF SPORT PHYSIOLOGY ,SARI BRANCH, ISLAMIC AZAD UNIVERSITY, SARI, IRAN
 
Abstract: 

Background and Objective: Increased oxidative damage to DNA can be mentioned as the main cause of age-related diseases. This damage can result in translation of specific genes which regulate cell proliferation and apoptosis. The aim of this study was to investigate the effect of a regular swimming training with garlic extract on the levels of Bax and Bcl-2 in the liver tissue doxorubicin -induced aging rat Materials and Methods: In this study, 42 aged male rats, 40-50 weeks, with an average initial weight of 250-300g were randomly divided into 6 groups: 1.
control, 2. saline, 3. doxorubicin, 4. doxorubicin+exercise, 5. doxorubicin+garlic, and 6. doxorubicin+garlic+exercise. Chronic kidney disease (CKD) was induced by injection of 8.5 ml/kg of doxorubicin. The animals in the exercise groups were forced to swim 30 min once a day, 3 days per week, for 8 weeks. Groups receiving supplement and exercise+supplement, daily treated with 1ml of garlic extract per kilogram of body weight for 8 weeks orally (gavage). In addition, 48 hours after the last training session and after 12-10 hours of fasting, rats were anesthetized and liver tissue separated immediately and stored at -70? C to measure the levels of Bax and Bcl-2. For comparisons among the groups, oneway analysis of variance (ANOVA) and Tukey’s test were performed with P<0.05 as an indication of statistical significance.
Results: The findings showed that eight weeks of swimming training and garlic extract and the combination of exercise training and garlic extract resulted in a significant increase in the levels of Bcl-2 and also a significant decrease in the levels of Bax and Bax/Bcl-2 in the kidney tissue of aged rats induced by doxorubicin (P<0.05).
Conclusion: Exercise training, herbal supplement of garlic, and a combination of these two methods can be as an effective non-pharmacological therapy to reduce liver damage and protect liver tissue against oxidative stress and inflammatory injuries associated with aging.

 
Keyword(s): AEROBIC TRAINING, GARLIC EXTRACT, APOPTOSIS, DOXORUBICIN
 
 
References: 
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Citations: 
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APA: Copy

SHAYESTEH RAD, F., & FARZANEGI, P., & HABIBIAN, M., & ALINEJAD, H. (2017). THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT. DANESHVAR MEDICINE, 24(129), 65-74. https://www.sid.ir/en/journal/ViewPaper.aspx?id=550117



Vancouver: Copy

SHAYESTEH RAD FATEMEH, FARZANEGI PARVIN, HABIBIAN MASOUMEH, ALINEJAD HADI. THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT. DANESHVAR MEDICINE. 2017 [cited 2021November28];24(129):65-74. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=550117



IEEE: Copy

SHAYESTEH RAD, F., FARZANEGI, P., HABIBIAN, M., ALINEJAD, H., 2017. THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT. DANESHVAR MEDICINE, [online] 24(129), pp.65-74. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=550117.



 
 
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