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Paper Information

Journal:   PAJOUHESH DAR PEZESHKI   Winter 2003-2004 , Volume 27 , Number 4 ; Page(s) 291 To 298.
 
Paper: 

INSULIN CHANGES IN PRE-ECLAMPTIC WOMEN DURING PREGNANCY

 
 
Author(s):  MALEK KHOSRAVI SH., KABOUDI B.
 
* 
 
Abstract: 

Background: Prior studies have shown an association between preeclampsia and increased levels of plasma insulin. The present study was conducted to compare the changes in fasting plasma insulin levels in preeclamptic women with normal controls during pregnancy.
Materials and methods: In a nested case-control study, 674 parturient, with normal blood pressure in the 20th gestational week, were followed through the second and third trimesters. Blood samples were obtained from 16 healthy and 16 preeclamptic women during the second and third trimesters to compare their insulin and glucose levels. Groups were matched according to age, parity, gestational age, and body mass index.
Results: The fasting insulin levels increased from 15.3
±1.3 µIu/ml to 25.3±1.4, between 2nd and 3rd trimesters in pre-eclamptic women (p<0.01) and from 10.4±0.9 to 16.2±1.3 µIu/ml in the control group (p<0.01). Fasting insulin level and its mean changes during the course of pregnancy were higher in preeclamptic women as compared to controls (p<0.01), whereas, there was no significant change in glucose levels during pregnancy in either group.
Conclusion: Women who develop preeclampsia have higher insulin levels before the clinical evidence of disease than women who remain normotensive during pregnancy; and this may increase further during the disease course'. These changes may be in association with insulin resistance in Na transport mechanism of cell membrane.

 
Keyword(s): PREECLAMPSIA, INSULIN CHANGES, PREGNANCY
 
 
References: 
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Citations: 
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APA: Copy

MALEK KHOSRAVI, S., & KABOUDI, B. (2004). INSULIN CHANGES IN PRE-ECLAMPTIC WOMEN DURING PREGNANCY. PAJOUHESH DAR PEZESHKI, 27(4), 291-298. https://www.sid.ir/en/journal/ViewPaper.aspx?id=54843



Vancouver: Copy

MALEK KHOSRAVI SH., KABOUDI B.. INSULIN CHANGES IN PRE-ECLAMPTIC WOMEN DURING PREGNANCY. PAJOUHESH DAR PEZESHKI. 2004 [cited 2021October24];27(4):291-298. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=54843



IEEE: Copy

MALEK KHOSRAVI, S., KABOUDI, B., 2004. INSULIN CHANGES IN PRE-ECLAMPTIC WOMEN DURING PREGNANCY. PAJOUHESH DAR PEZESHKI, [online] 27(4), pp.291-298. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=54843.



 
 
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