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Paper Information

Journal:   BINA   WINTER 2017 , Volume 22 , Number 2; Page(s) 104 To 109.
 
Paper: 

ASSOCIATION BETWEEN POLYMORPHISMS OF RS4151667(L9H) CFB GENE AND AGE-RELATED MACULAR DEGENERATION IN A POPULATION IN THE NORTH WEST OF IRAN

 
 
Author(s):  ROSHANIPOUR N., JABBARPOUR BONYADI M.*, JABBARPOUR BONYADI M.H., JAVADZADEH A.
 
* UNIVERSITY OF TABRIZ, TABRIZ, IRAN
 
Abstract: 
Purpose: To investigate the possible association of polymorphisms of rs4151667 (L9H) B gene with age-related macular degeneration (AMD) in a population from the North West of Iran.Methods: In this study, 56 patients with AMD and 144 age-, sex-, and ethnic-matched controls were recruited. Both patients and controls were selected from the North West of Iran. The association of polymorphisms of rs4151667 (L9H) CFB gene with AMD was investigated using polymerase chain reaction (PCR) and digested fragment length polymorphism technique (RFLP).Results: A significant association was found between the polymorphism of rs4151667 (L9H) CFB gene and AMD disease. (P=0.01 for TT genotype and P=0.02 for AT genotype) Conclusion: The TT genotype increases the likelihood of AMD by 2.6 times as compared to genotypes other than TT, whereas the AT genotype has a protective effect against the disease.
 
Keyword(s): AMD, CFB GENE, PCR-RFLP, POLYMORPHISM
 
 
References: 
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Citations: 
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APA: Copy

ROSHANIPOUR, N., & JABBARPOUR BONYADI, M., & JABBARPOUR BONYADI, M., & JAVADZADEH, A. (2017). ASSOCIATION BETWEEN POLYMORPHISMS OF RS4151667(L9H) CFB GENE AND AGE-RELATED MACULAR DEGENERATION IN A POPULATION IN THE NORTH WEST OF IRAN. BINA, 22(2), 104-109. https://www.sid.ir/en/journal/ViewPaper.aspx?id=548367



Vancouver: Copy

ROSHANIPOUR N., JABBARPOUR BONYADI M., JABBARPOUR BONYADI M.H., JAVADZADEH A.. ASSOCIATION BETWEEN POLYMORPHISMS OF RS4151667(L9H) CFB GENE AND AGE-RELATED MACULAR DEGENERATION IN A POPULATION IN THE NORTH WEST OF IRAN. BINA. 2017 [cited 2021December04];22(2):104-109. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=548367



IEEE: Copy

ROSHANIPOUR, N., JABBARPOUR BONYADI, M., JABBARPOUR BONYADI, M., JAVADZADEH, A., 2017. ASSOCIATION BETWEEN POLYMORPHISMS OF RS4151667(L9H) CFB GENE AND AGE-RELATED MACULAR DEGENERATION IN A POPULATION IN THE NORTH WEST OF IRAN. BINA, [online] 22(2), pp.104-109. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=548367.



 
 
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