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Paper Information

Journal:   JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   JUNE 2017 , Volume 27 , Number 149; Page(s) 181 To 186.
 
Paper: 

RELATIONSHIP BETWEEN P16 EXPRESSION AND BREAST CANCER USING HISTOLOGY AND IMMUNOHISTOCHEMISTRY

 
 
Author(s):  GOLMOHAMMADI RAHIM, ELYASI HOSSEIN, GOLMOHAMMADI MOTAHAERH
 
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Abstract: 

Background and purpose: Studying the expression of P16 gene which is a tumor suppressor in breast cancer is beneficial for clinical and pathological studies. The purpose of this study was to determine the expression of P16 gene in breast cancer samples using histological and immunohistochemical analyses.
Materials and methods: This descriptive analytical research was conducted in 100 breast cancer samples obtained from Eemdad Shhid Beheshti Hospital in Sabzevar, Iran. The samples were fixed in formalin and sections were processed, then, the slides were stained. The diagnosis was made by two pathologists. Data analysis was done in SPSS V16 using Chi- square test.
Results: A total of 100 specimens was studied in which the overexpression of P16 gene was detected in 82 (82%), while in 18 (18%) malignant samples no overexpression was found. Overexpression of the gene was not found in normal samples too. There were significant relationships between high grade tumors and stage of tumors with overexpression of P16 (P<0.001, P<0.46, respectively).
Conclusion: In current study, the P16 overexpression was observed more in patients with high grade tumors. Therefore, the overexpression of this gene indicates a poor prognosis in breast cancer.

 
Keyword(s): BREAST CANCER, P16 EXPRESSION, IMMUNOHISTOCHEMISTRY, HISTOCHEMISTRY
 
References: 
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