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Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   AUGUST-SEPTAMBER 2015 , Volume 22 , Number 135; Page(s) 115 To 121.
 
Paper: 

EFFECT OF VARIOUS DOSES OF LAVANDULA OFFICINALIS ON ACUTE PAIN IN RAT

 
 
Author(s):  RABIEI ZAHRA, HOJJATI MOHAMMAD REZA, MORADI NAFCHI ATEFEH, RAFIEIAN KOPAEI MAHMOUD*
 
* MEDICAL PLANTS RESEARCH CENTER, SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, SHAHREKORD, IRAN
 
Abstract: 

Background: The use of medicinal plants is important in reducing pain. Extracts obtained from the leaves of Lavandula officinalis (Lamiaceae) are used in Iranian folk medicine as remedies for anti-nociceptive effects. This study was aimed to investigate the effects of pretreatment with different doses of Lavandula officinalis ethanolic extract on hot plate induced nociception in male Wistar rats.
Methods: This experimental study was carried out on 28 male Wistar rats weighing 200-250 g. Acute pain was investigated using a hot plate test with set point 52.8oC and cut off time of 60 seconds. In this experiment rats were divided into 4 groups. Control group received distilled water and three treatment groups received different doses of lavender ethanolic extract (100, 200, 400 mg/kg, respectively) 1 hour prior beginning of experiment via gastric gavage. The data were compared using one way ANOVA (post hoc LSD).
Results: Lavender extract with 400 mg/kg dose significantly increased latency to respond to heat stimulus 5 and 15 minutes after beginning of the experiment.
Conclusion: Although further studies are needed, the results indicate that lavender extract might be beneficial in patients suffering pain.

 
Keyword(s): LAVANDULA OFFICINALIS, HOT PLATE, PAIN
 
References: 
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  Persian Abstract Yearly Visit 78
 
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