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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   DECEMBER 2016 , Volume 45 , Number 12; Page(s) 1625 To 1635.
 
Paper: 

ASSOCIATION OF COX-2 PROMOTER POLYMORPHISMS -765G/C AND -1195A/G WITH MIGRAINE

 
 
Author(s):  MOZAFFARI ELAHE*, DOOSTI ABBAS, ARSHI ASGHAR, FAGHANI MOSTAFA
 
* BIOTECHNOLOGY RESEARCH CENTER, ISLAMIC AZAD UNIVERSITY, SHAHREKORD BRANCH, SHAHREKORD, IRAN
 
Abstract: 

Background: Migraine is a common debilitating primary headache disorder with current head pain attacks, which contributes to physical activity dysfunctions in chronic pain phase. PGE2 and PGI2 are two important prostaglandins synthesised by COX-2 enzymes, involved in migraine pain signals. COX-2 modulation is essential in treatment and pathogenesis of migraine. This study aimed to investigating the association between COX-2 gene polymorphisms with the risk of migraine susceptibility in migraine patients with related and unrelated parents.
Methods: This case- control study was based on 100 migraine patients and 100 non-migraine subjects in Bushehr province, Iran in 2013. Genomic DNA of blood samples was extracted and genotyping of COX-2-765G>C (rs20417) and COX-2-1195A>G (rs689466) gene variants was investigated by PCR-RFLP method. Statistical analyses were ac-complished using the SPSS software package.
Results: There was a significant differences in the frequencies of the COX-2-765G>C and COX-2-1195A>G genotypes between migraine patients and controls (P?0.05).
Conclusion: COX-2-765CC, COX-2-765CG, COX-2-1195GG and COX-2-1195AG genotypes can increase the risk of migraine significantly. As the first study in Iran, we are hopeful to achieve greater results about the relevancy of COX-2 gene, migraine and pain signals pathway by repeating these experiments on more samples

 
Keyword(s): MIGRAINE, COX-2 GENE, POLYMORPHISM, RFLP, IRAN
 
References: 
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