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Paper Information

Journal:   JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES   Spring 2001 , Volume 8 , Number 2; Page(s) 88 To 94.
 
Paper: 

EXPERIMENTAL STUDY TO EVALUATE THE PRETREATMENT OF MELISSA OFFICINALIS EXTRACT AGAINST LETHAL SEIZURES INDUCED BY PENTYLENTETRAZOLE IN WISTAR RATS

 
 
Author(s):  MAHMOUDI M., HEIDARI M.R., ZOHOUR A.R
 
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Abstract: 

Melissa officinalis is a well known medicinal plant. Different studies performed in mice have shown the sedative, hypnotic, analgesic, antiviral and antimicrobial effects of this plant. The present investigation was undertaken to evaluate the effect of percolated extract of this plant against lethal seizure induced by intraregional injection of pentylentetrazole (PTZ) in wistar rats. The study was performed on three groups of animals pretreated with different doses of extract via intraperitonal injection. After 30 minutes each animal received high dose of PTZ (90 mg/kg) for induction of lethal seizure. The control group received normal saline. In addition a positive control group pretreated with diazepam, a well known drug in the treatment of seizure, was used for comparison. The efficacy of the extract to protect the animals against lethal seizure was based on the latency of the appearance of the first sign of seizure or the latency of the different epileptic manifestations and decrease of mortality rate in each group. The results showed that various epileptic manifestations are delayed in diazepam pretreated animals and extract compared with control group. The dose of 50 mg/kg of the extract appeared to be significantly effective on the tremors and the myoclonic jerks of epileptic manifestations (P<0.05). In addition the mortality rate was significantly reduced in pretreated animals with this dose compared with control group (P<0.05). Mortality rate was 88% in saline group, 13% in 50mggroup and zero percent in diazepam group. The results indicated. that the extract of Melissa officinalis possesses anticonvulsant property.

 
Keyword(s): MELISSA OFFICINALIS, SEIZURE, PENTYLENTETRAZOLE, ANTICONVULSANT ACTIVITY, RAT
 
References: 
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