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Journal:   HORMOZGAN MEDICAL JOURNAL   APRIL 2017 , Volume 21 , Number 1; Page(s) 1 To 9.
 
Paper: 

Renoprotective Effects Of Gaba On Ischemia/Reperfusion- Induced Renal Injury In Hyperglycemic Male And Female Rats

 
DOI: 

10.18869/acadpub.hmj.21.1.1

 
Author(s):  Soltani Nepton*, Tighsaz Yousef, Nematbakhsh Mehdi
 
* MOLECULAR MEDICINE RESEARCH CENTER, HORMOZGAN HEALTH INSTITUTE, HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES, BANDAR ABBAS, IRAN
 
Abstract: 
Introduction: Acute kidney injury (AKI) has been known as a complex clinical complication in diabetic patients. The main cause of AKI is ischemia/reperfusion injury (IRI). This study was designed to investigate the protective effects of GABA on renal IRI in hyperglycemic female and male rats.Methods: Sixty STZ induced diabetic male and female Wistar rats were categorized in 10 groups (5 female & 5 male groups). Groups 1-3 in each gender received GABA (10, 50, 100?mol/kg/day) for 3 days, and then were subjected to renal IRI.Group 4 in each gender was subjected to renal IRI alone, and group 5 was subjected to surgical operation without renal IRI.24 hr after I/R injury, blood sample was obtained, and the animal were sacrificed for pathology investigation.Results: Renal IRI alone increased the serum blood urea nitrogen levels (BUN) and creatinine (Cr), and kidney damage in both male and female rats significantly (P<0.05), however all doses of GABA decreased the serum BUN and Cr levels and tissue damage when compared with control group.Conclusion: From the results of this study it seems that GABA administration in hyperglycemic rats could decrease renal injury after an ischemia/reperfusion.
 
Keyword(s): ISCHEMIA, REPERFUSION, DIABETES, GABA, RAT
 
 
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APA: Copy

SOLTANI, N., & TIGHSAZ, Y., & NEMATBAKHSH, M. (2017). RENOPROTECTIVE EFFECTS OF GABA ON ISCHEMIA/REPERFUSION- INDUCED RENAL INJURY IN HYPERGLYCEMIC MALE AND FEMALE RATS. HORMOZGAN MEDICAL JOURNAL, 21(1), 1-9. https://www.sid.ir/en/journal/ViewPaper.aspx?id=541431



Vancouver: Copy

SOLTANI NEPTON, TIGHSAZ YOUSEF, NEMATBAKHSH MEHDI. RENOPROTECTIVE EFFECTS OF GABA ON ISCHEMIA/REPERFUSION- INDUCED RENAL INJURY IN HYPERGLYCEMIC MALE AND FEMALE RATS. HORMOZGAN MEDICAL JOURNAL. 2017 [cited 2022June29];21(1):1-9. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=541431



IEEE: Copy

SOLTANI, N., TIGHSAZ, Y., NEMATBAKHSH, M., 2017. RENOPROTECTIVE EFFECTS OF GABA ON ISCHEMIA/REPERFUSION- INDUCED RENAL INJURY IN HYPERGLYCEMIC MALE AND FEMALE RATS. HORMOZGAN MEDICAL JOURNAL, [online] 21(1), pp.1-9. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=541431.



 
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