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Paper Information

Journal:   NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM   WINTER 2016 , Volume 4 , Number 1; Page(s) 1 To 6.
 
Paper: 

EFFECT OF GALLIC ACID AND ENDURANCE EXERCISE TRAINING ON BDNF IN A MODEL OF HIPPOCAMPAL DEGENERATION

 
DOI: 

10.18869/acadpub.shefa.4.1.1

 
Author(s):  RAFIEI SAMANEH, BAZYAR YUNES, EDALATMANESH MOHAMMAD AMIN*
 
* DEPARTMENT OF PHYSIOLOGY, COLLEGE OF SCIENCES, SHIRAZ BRANCH, ISLAMIC AZAD UNIVERSITY, SHIRAZ, IRAN
 
Abstract: 

Introduction: The aim of this study was to investigate the effect of gallic acid on hippocampal level of brain derivative neurotrophic factor (BDNF) in trimethyltin chloride (TMT) - intoxication rats after eight weeks of endurance training.
Materials and Methods: Seventy Sprague-dawley male rats were selected and randomly divided into seven groups, including: (1) Control, (2) Sham, (3) Gallic acid 50, (4) Gallic acid 100, (5) Endurance training (4), (6) Training+Gallic acid 50, and (7) Training+Gallic acid 100.
Hippocampal degeneration was induced by TMT (8 mg/kg) in all groups except control animals. During eight weeks, rats of groups 3, 6 and 7 ran on treadmill’s without incline at a speed of 15 to 20 meters per minute for 15 to 30 minutes per session, five times weekly.
In addition, groups 4 and 6 were treated with gallic acid (50 mg/kg) and groups 5 and 7 with gallic acid (100 mg/kg) every day for 14 days.
Results: The findings showed that hippocampal levels of BDNF in all test groups was significantly higher than sham group.
Conclusion: Endurance training and gallic acid as well as the combination of them increase the level of hippocampal BDNF in a model of TMT-intoxication.

 
Keyword(s): HIPPOCAMPUS, PHYSICAL ENDURANCE, GALLIC ACID, BRAIN-DERIVED NEUROTROPHIC, FACTOR
 
References: 
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