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Paper Information

Journal:   ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)   SEPTEMBER 2016 , Volume 19 , Number 6 (111); Page(s) 57 To 67.
 
Paper: 

THE EFFECT OF ACTIVE VITAMIND ON TREATMENT OF PROTEINURIA IN PATIENTS WITH DIABETIC NEPHROPATHY WITHOUT VITAMIN D DEFICIENCY

 
 
Author(s):  SAEEDI NADER*, REZVANFAR MOHAMMADREZA, HADIDI MEHDI, ASGHARIZADEH MAHANI FARVAH, AHMADLOU MOJTABA
 
* DEPARTMENT OF INTERNAL MEDICINE, ARAK UNIVERSITY OF MEDICAL SCIENCES, ARAK, IRAN
 
Abstract: 

Background: The renin-angiotensin system (RAS) has a major role in development of diabeticnephropathy and blocking of RAS by inhibitors and blocking of angiotesin receptors is standardtreatment for preventing kidney disease and proteinuria. It is reported that VIT-D analogues are able tosuppress renin exertion and improve proteinuria. The aim of this study is to evaluate the effect of VitDanalogue (calitriol) on reducing proteinuria in patients with diabetic nephropathy.
Materials and Methods: In this clinical trial study, 132 eligible patients that had diabeticnephropathy and hadn’t vit D deficiency were selected. The patients were divided into two equalgroups. First group received the combination of losartan 25mg twice daily and calcitriol 0.25mg andsecond group received losartan 25 mg twice daly alone for 3 months. The FBS, lipid profile, ESR-CRPBUN, Cr, HbA1c, Ca, P, and 24 hours urine protein were evaluated in all patients at beginning and endof study and the results were statistcally compared.
Results: The 24-hour urine protein in losartan and calitriol group was improved compared tolosartan. This difference was statistically significant (p=0.003). As well as, in kidney function (BUN, Cr) in the losartan and calcitriol group compared to losartan alone was significantly improved (p<0.05).
Conclusion: Combination of calcitriol with angiotesin receptor blockers (ARBs) is moreeffective than ARBs alone in improvement of proteinuria and real function.

 
Keyword(s): CHORNIC KIDNEY DISEASES, DIABETIC NEPHROPHTY, VITD, LOSARTAN, PROTEINURIA, CALCITRIOL
 
References: 
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