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Paper Information

Journal:   JOURNAL OF CELL & TISSUE   SPRING 2016 , Volume 7 , Number 1; Page(s) 9 To 17.
 
Paper: 

STUDY OF HYPOGLYCEMIC EFFECT OF TRAGOPOGON GRAMINIFOLIUS L. HYDROALCOHOLIC LEAF'S EXTRACT IN NORMAL AND DIABETIC MALE RATS

 
 
Author(s):  ZIAFATDOOST ABED D., MIRAZI N.*
 
* DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCES, BU-ALI SINA UNIVERSITY, HAMEDAN, IRAN
 
Abstract: 

Aim: The aim of this study was to evaluate the anti-diabetic effects of Tragopogon graminifolius hydroethanolic leaf's extract (TGE) on blood glucose and insulin level in diabetes male rats.
Material and methods: In this experimental study 42 Wistar male rats were randomly divided in 6 groups: control, diabetic (streptozotocin60 mg/kg, i.p), experimental diabetic groups (treatment with TGE, 200, 400 and 800 mg/kg, i.p) and diabetic treatment with metformin (500mg/kg, gavaged) for 10 days. The blood glucose was examined daily by glucometer. At the end of examination blood samples and pancreatic tissue were collected for insulin evaluation and histological study. All data are expressed as mean±SEM and statistical significance was considered at p<0.05.
Results: Treatment with the 800 mg/kg TGE decreased significantly blood glucose in diabetic rats compared with control group (P<0.05). In addition, administration of 400 and 800 mg/kg of TGE could significantly decreased plasma glucose levels compared with metformin group. The insulin blood levels increased significantly in treated groups compared with diabetic group (P<0.05).
Conclusion: The TGE has flavonoid and phenolic compositions and its prescription might be decrease blood glucose and increase blood insulin levels in diabetic rats.

 
Keyword(s): DIABETE, TRAGOPOGON GRAMINIFOLIUS, GLUCOSE, RAT
 
References: 
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