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Paper Information

Journal:   PATHOBIOLOGY REAEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)   WINTER 2015 , Volume 17 , Number 4; Page(s) 13 To 24.
 
Paper: 

ONE-STEP SYNTHESIS OF ANIONIC PEG-CITRATE G2 DENDRIMER AND EVALUATION OF ITS CYTOTOXICITY IN TWO CELL LINES

 
 
Author(s):  EBRAHIMI SAEIDEH, SADEGHIZADEH MAJID*, AGHASADEGHI MOHAMMAD REZA*, SHAFIEE ARDESTANI MEHDI, BEHMANESH MEHRDAD
 
* P.O.CODE: 1739614595, DEPARTMENT OF HEPATITIS AND AIDS, PASTEUR INSTITUTE OF IRAN, TEHRAN, IRAN
 
Abstract: 
Objective: Dendrimers are three-dimensional nanostructures that have numerous applications in medicine, including drug delivery and imaging. Although anionic dendrimer polyethylene glycol–citrate has a high potential to increase solubility of waterinsoluble drugs and drug delivery, its multi-step synthesis procedure is time consuming.In addition, toxic substances such as dichloromethane are used in its synthesis procedure.In this study, we have developed a simple one-step synthesis method using green chemistry.Methods: We examined four different methods to improve the synthesis method of this dendrimer. Products were characterized by FTIR, LC-MS and DLS. Cytotoxicity was assessed by the XTT method.Results: We synthesized a G2 polyethylene glycol–citrate dendrimer in one-step without purifying G1. This process was chosen as a beneficial method for synthesis of the G2 dendrimer. When compared with previous methods, this procedure had higher efficiency and greatly reduced response. This procedure used nontoxic materials. XTT assay results showed that this dendrimer created by green chemistry had no cytotoxicity in Hela and Vero cells up to a concentration of 800 ?M.Conclusion: One-step synthesis of anionic polyethylene glycol-citrate G2 dendrimer is a simple, beneficial production method. The dendrimer is biocompatible and can be used as a suitable carrier for drug delivery purposes.
 
Keyword(s): DENDRIMER, IMPROVEMENT, BIODEGRADABLE, PEG-CITRIC ACID, GREEN CHEMISTRY
 
 
References: 
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APA: Copy

EBRAHIMI, S., & SADEGHIZADEH, M., & AGHASADEGHI, M., & SHAFIEE ARDESTANI, M., & BEHMANESH, M. (2015). ONE-STEP SYNTHESIS OF ANIONIC PEG-CITRATE G2 DENDRIMER AND EVALUATION OF ITS CYTOTOXICITY IN TWO CELL LINES. PATHOBIOLOGY REAEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 17(4), 13-24. https://www.sid.ir/en/journal/ViewPaper.aspx?id=523376



Vancouver: Copy

EBRAHIMI SAEIDEH, SADEGHIZADEH MAJID, AGHASADEGHI MOHAMMAD REZA, SHAFIEE ARDESTANI MEHDI, BEHMANESH MEHRDAD. ONE-STEP SYNTHESIS OF ANIONIC PEG-CITRATE G2 DENDRIMER AND EVALUATION OF ITS CYTOTOXICITY IN TWO CELL LINES. PATHOBIOLOGY REAEARCH (MODARES JOURNAL OF MEDICAL SCIENCES). 2015 [cited 2021December09];17(4):13-24. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=523376



IEEE: Copy

EBRAHIMI, S., SADEGHIZADEH, M., AGHASADEGHI, M., SHAFIEE ARDESTANI, M., BEHMANESH, M., 2015. ONE-STEP SYNTHESIS OF ANIONIC PEG-CITRATE G2 DENDRIMER AND EVALUATION OF ITS CYTOTOXICITY IN TWO CELL LINES. PATHOBIOLOGY REAEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), [online] 17(4), pp.13-24. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=523376.



 
 
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