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Paper Information

Journal:   JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   DECEMBER 2016 , Volume 26 , Number 143; Page(s) 28 To 36.
 
Paper: 

IN VIVO PROTECTIVE EFFECT OF MYRICETIN ON LIVER BIOCHEMICAL DAMAGE INDUCED BY ENDOSULFAN

 
 
Author(s):  SHOKRZADEH MOHAMMAD, EBRAHIMNEJAD HANIEH, ZEAR ALI, CHABRA AROONA, NAGHSHVAR FARSHAD, AHMADI AMIRHOSSEIN
 
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Abstract: 

Background and purpose: Endosulfan is an organochlorine insecticide that is absorbed orally, subcutaneously and by inhalation in humans and animals and disturbs the reduction process, changes the activity of antioxidant enzymes and increases the lipid peroxidation in many organs. The aim of this study was to evaluate the protective effect of myricetin against endosulfan induced liver damage.
Materials and methods: In an experimental study 42 male Wister rats were randomly divided into 7 groups (n=6 per group). GroupI served as the control and the experimental groups were as follows: groupII- ? received endosulfan 10 mg/kg and myricetin 5, 10, 15, and 20 mg/kg/ip for 30 days, respectively. Group?I was treated only by 10 mg/kg endosulfan and group ?II as positive control received 10 mg/kg cyclophosphamide (ip, 30 days). Twenty four hours after the last injection, all rats were anesthetized using ethyl ether. Alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and superoxide dismutase (SOD) levels were measured in plasma. Liver glutathione (GSH) levels were also determined.
Results: Administration of endosulfan caused elevation in ALT, AST, ALP and SOD levels, but the activity of GSH decreased in liver tissue. Receiving myricetin along with endosulfan significantly increased body antioxidant activity and normalized the liverenzyme levels (P? 0.05).
Conclusion: Our results indicated that myricetin with antioxidant effect could protect cells against harmful free radicals. Therefore, further clinical trials are suggested.

 
Keyword(s): ENDOSULFAN, ANTIOXIDANTS, GLUTATHIONE, LIVER
 
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