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Paper Information

Journal:   INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL   WINTER 2016 , Volume 3 , Number 1; Page(s) 25 To 31.
 
Paper: 

Effect Of Magnetic Tacrine-Loaded Chitosan Nanoparticles On Spatial Learning, Memory, Amyloid Precursor Protein And Seladin-1 Expression In The Hippocampus Of Streptozotocin-Exposed Rats

 
 
Author(s):  Hassanzadeh Golamreza, Fallahi Zahra, Khanmohammadi Mohammad, Elmizadeh Hamideh, Sharifzadeh Mohammad, Nouri Kosar, Heydarian Zahra, Mahakizadeh Simin, Zendedel Adib, Beyer Cordian, Mohseni Kouchesfahani Homa*
 
* DEPARTMENT OF ANIMAL BIOLOGY, FACULTY OF BIOLOGICAL SCIENCE, KHARAZMI UNIVERSITY, TEHRAN, IRAN
 
Abstract: 
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory and cognitive dysfunction due to neuronal cell loss in higher brain centers. Senile plaques containing amyloid b (Ab) are associated with this disease as well as a reduction in cholinergic neuron numbers. Tacrine is a reversible cholinesterase inhibitor in clinical use to treat moderate forms of AD. Chitosan nanoparticles represent an effective systemic delivery system for drugs. The application of tacrine-loaded chitosan nanoparticles has been shown to selectively increase tacrine concentrations in the brain tissue. In this study, we compared magnetic and non-magnetic tacrineloaded chitosan nanoparticles for their bioactivity and neuroprotective potency in streptozotocin (stz)-induced neurodegeneration, an accepted animal model for AD. Male rats received a single injection of stz via an implanted cannula into the lateral brain ventricle. Tacrine (tac)-loaded chitosan nanoparticles were delivered into the tail vein. Spatial learning and memory were analyzed using the Morris water maze task. Amyloid precursor protein gene (APP) and seladin-1 gene expression were studied in the hippocampus by real time-PCR. Tac-loaded non-magnetic and tac-loaded magnetic chitosan nanoparticles improved spatial learning and memory after stz treatment with magnetic nanoparticles being most effective. Similarly, tac-loaded chitosan nanoparticles increased seladin-1 and reduced APP gene expression. Again, magnetic nanoparticles were more effective. These data reveal that tac-loaded non magnetic and tac-loaded magneticchitosan nanoparticles to a higher extent improve brain deficits related to stz application. We conclude that the magnetic target drug delivery system is a promising therapeutic strategy to protect AD-related degenerating in the CNS.
 
Keyword(s): ALZHEIMER, NANOPARTICLES, TACRINE, CHITOSAN, MORRIS WATER MAZE, SELADIN-1, AMYLOID-βHIPPOCAMPUS
 
 
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APA: Copy

HASSANZADEH, G., & FALLAHI, Z., & KHANMOHAMMADI, M., & ELMIZADEH, H., & SHARIFZADEH, M., & NOURI, K., & HEYDARIAN, Z., & MAHAKIZADEH, S., & ZENDEDEL, A., & BEYER, C., & MOHSENI KOUCHESFAHANI, H. (2016). EFFECT OF MAGNETIC TACRINE-LOADED CHITOSAN NANOPARTICLES ON SPATIAL LEARNING, MEMORY, AMYLOID PRECURSOR PROTEIN AND SELADIN-1 EXPRESSION IN THE HIPPOCAMPUS OF STREPTOZOTOCIN-EXPOSED RATS. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, 3(1), 25-31. https://www.sid.ir/en/journal/ViewPaper.aspx?id=513702



Vancouver: Copy

HASSANZADEH GOLAMREZA, FALLAHI ZAHRA, KHANMOHAMMADI MOHAMMAD, ELMIZADEH HAMIDEH, SHARIFZADEH MOHAMMAD, NOURI KOSAR, HEYDARIAN ZAHRA, MAHAKIZADEH SIMIN, ZENDEDEL ADIB, BEYER CORDIAN, MOHSENI KOUCHESFAHANI HOMA. EFFECT OF MAGNETIC TACRINE-LOADED CHITOSAN NANOPARTICLES ON SPATIAL LEARNING, MEMORY, AMYLOID PRECURSOR PROTEIN AND SELADIN-1 EXPRESSION IN THE HIPPOCAMPUS OF STREPTOZOTOCIN-EXPOSED RATS. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL. 2016 [cited 2022January26];3(1):25-31. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=513702



IEEE: Copy

HASSANZADEH, G., FALLAHI, Z., KHANMOHAMMADI, M., ELMIZADEH, H., SHARIFZADEH, M., NOURI, K., HEYDARIAN, Z., MAHAKIZADEH, S., ZENDEDEL, A., BEYER, C., MOHSENI KOUCHESFAHANI, H., 2016. EFFECT OF MAGNETIC TACRINE-LOADED CHITOSAN NANOPARTICLES ON SPATIAL LEARNING, MEMORY, AMYLOID PRECURSOR PROTEIN AND SELADIN-1 EXPRESSION IN THE HIPPOCAMPUS OF STREPTOZOTOCIN-EXPOSED RATS. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, [online] 3(1), pp.25-31. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=513702.



 
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