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Paper Information

Journal:   PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)   FALL 2015 , Volume 13 , Number 3; Page(s) 45 To 50.
 
Paper: 

PROTECTIVE EFFECT OF ALOE VERA ALCOHOLIC EXTRACT GEL ON CHANGES OF ESTROGEN AND PROGESTERONE IN EXPERIMENTAL MODEL RATS WITH MS

 
 
Author(s):  RAHMANIAN KOSHKAKI ELHAM*, TAJALI MINA, TAHERIANFARD MAHNAZ
 
* DEPT. OF ANATOMY AND EMBRYOLOGY, INTERNATIONAL BRANCH, SHIRAZ UNIVERSITY, SHIRAZ, IRAN
 
Abstract: 

Multiple Sclerosis (MS) is a disease of central nervous system. Researchers have turned to traditional medicine for the treatment of MS. The present article aimed to investigate the protective effect of Aloe Vera alcoholic extract gel on changes of estrogen and progesterone in experimental MS models of female rats.
Materials and Methods: A total number of 30 female Wistar rats were randomly divided into 6 equal groups. The experimental group 1 received 14 micro liters of ethidium bromide in lateral ventricles and received normal saline gavage; the experimental group 2 received 14 micro liters of ethidium bromide in lateral ventricles and received 50 mg/Kg of Aloe Vera; the experimental group 3 received 14 micro liters of ethidium bromide in lateral ventricles and received 100 mg/Kg of Aloe Vera, the experimental group 4 received 14 micro liters of ethidium bromide in lateral ventricles and received 200 mg/Kg of Aloe Vera. The control group did not receive any drugs. The sham group received 14 micro liters saline in lateral ventricles.. Finally, blood samples were taken from their hearts in order to measure the serum concentration of estrogen and progesterone.
Results: The serum concentration of estrogen in the sham group, experimental groups 1 and 2 was significantly lower than that in the control group. The concentration of progesterone in the sham group, experimental groups 1, 2 and 3 was significantly lower than that in the control group..
Conclusion: The results show that MS decreased estrogen and progesterone, and that the active ingredients of Aloe Vera increased the concentration of the estrogen and progesterone in rats with MS.

 
Keyword(s): ALOE VERA, ESTROGEN, PROGESTERONE, MS
 
References: 
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