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Paper Information

Journal:   JOURNAL OF DIABETES AND METABOLIC DISORDERS   Spring 2006 , Volume 5 , Number 3; Page(s) 209 To 215.
 
Paper: 

A COMMON POLYMORPHISM IN THE PROMOTER OF UCP2 GENE IN AN IRANIAN NORMAL POPULATION

 
 
Author(s):  HEYDARI JAVAD, HESHMAT RAMIN, AMIRI P., FAKHRZADEH H., PAZHOUHI M., AKRAMI S.M.*
 
* Endocrinology and Metabolism Research Center, Dr Shariati Hospital, North Kargar Ave, Tehran 14114, Iran
 
Abstract: 

Background: Uncoupling protein-2 (UCP2), one of the mitochondrial transporter memborane protiens, is suggested as a contributor gene for obesity. A common G/A polymorphism in the UCP2 promoter region is associated with obesity and diabetes.
Methods: As a cross-sectional study, 75 healthy 25-64 years volunteers were randomly selected from Tehran University of Medical Sciences population Lab. DNA was exracted from blood samples then polymorphism and A & G Allel frequencies were determined via PCR and RFLP. The correlation between genotype and such clinical and biochemical parameters as BMI, serum cholesterol and TG was investigated. Results were compared with other similar surveys.
Results: The frequencies of the UCP2 -866G/A genotypes in 75 Iranian normal population were AA: 7 (9.4%), GA: 41 (54.6%), and GG: 27 (36%).
Conclusion: Significantly higher HDL cholesterol was detected in people with GG allele (P=0.02) as compared with GA and AA alleles. 866 UCP2 G/A genotype frequencies in our study were significantly different as compared with Japanese population but no with European studies that may emphasize on genetical similarity between Iranian and European Caucasians populations.

 
Keyword(s): UCP2, POLYMORPHISM, PCR/RFLP
 
References: 
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