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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number SUPPL; Page(s) 71 To 77.
 
Paper: 

DESIGN, SYNTHESIS AND CYTOTOXICITY EVALUATION OF NEW 2-ARYL-5, 6-DIHYDROPYRROLO [2, 1-A]ISOQUINOLINE DERIVATIVES AS TOPOISOMERASE INHIBITORS

 
 
Author(s):  KAKHKI SAMANEH, SHAHOSSEINI SORAYYA, ZARGHI AFSHIN*
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, SCHOOL OF PHARMACY, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Two set of 2-aryl-5, 6-dihydropyrrolo [2, 1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithelial cells), T47D (Human ductal breast epithelial tumor cell line) and Hela (Human cervix cancer). According to our results, HepG2 seems to be the most sensitive cell line for these compounds with mean IC50 values ranging from 4.25 to 70.05 mM. Our results indicated that compound 7b exhibited the best potency against the tested cell lines. These results also suggest that pyrroloisoquinoline moiety constitutes a suitable scaffold to design new anti-proliferative agents.

 
Keyword(s): PYRROLO [2, 1-A] ISOQUINOLINES, TOPOISOMERASE INHIBITORS, MOLECULAR MODELING, CYTOTOXICITY
 
 
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Citations: 
 
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APA: Copy

KAKHKI, S., & SHAHOSSEINI, S., & ZARGHI, A. (2014). DESIGN, SYNTHESIS AND CYTOTOXICITY EVALUATION OF NEW 2-ARYL-5, 6-DIHYDROPYRROLO [2, 1-A]ISOQUINOLINE DERIVATIVES AS TOPOISOMERASE INHIBITORS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(SUPPL), 71-77. https://www.sid.ir/en/journal/ViewPaper.aspx?id=490206



Vancouver: Copy

KAKHKI SAMANEH, SHAHOSSEINI SORAYYA, ZARGHI AFSHIN. DESIGN, SYNTHESIS AND CYTOTOXICITY EVALUATION OF NEW 2-ARYL-5, 6-DIHYDROPYRROLO [2, 1-A]ISOQUINOLINE DERIVATIVES AS TOPOISOMERASE INHIBITORS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR). 2014 [cited 2021June22];13(SUPPL):71-77. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=490206



IEEE: Copy

KAKHKI, S., SHAHOSSEINI, S., ZARGHI, A., 2014. DESIGN, SYNTHESIS AND CYTOTOXICITY EVALUATION OF NEW 2-ARYL-5, 6-DIHYDROPYRROLO [2, 1-A]ISOQUINOLINE DERIVATIVES AS TOPOISOMERASE INHIBITORS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), [online] 13(SUPPL), pp.71-77. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=490206.



 
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