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Journal:   JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   Fall 2001 , Volume 8 , Number 3 (21); Page(s) 10 To 21.
 
Paper: 

Designing And Synthesis Of Morphine Vaccine

 
 
Author(s):  Akbarzadeh A., Farahmand B.
 
* 
 
Abstract: 
A morphine-6-succinyl-BSA (M-6-S-BSA) hapten was designed in an effort to obtain a potent, long-lasting anti-morphine immune response for the treatment of morphine abuse. The analogue incorporated a succinic anhydride linker moiety in place of hydroxy group at C-6 of the morphine framework. Then morphine 6-hemisuccinate was conjugated to BSA in aqueous solution in the presence of water-soluble carbodi imide. M-6-S-BSA was synthesized in three chemical steps starting from morphine sulphate, and the extent of conjugation was determined by base hydrolysis of the conjugate, extraction and measurement of free morphine. Averages of 6.5 molecules of morphine were conjugated to each molecule of protein. Six rats, Albino wistar strain, immunized with various doses of the conjugate, were found to be producing antibody 8 weeks later, as determined by a modification of the (NH4) 2SO4 method, which measures primary binding of antigen by antibody.
 
Keyword(s): MORPHINE VACCINE
 
 
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APA: Copy

AKBARZADEH, A., & FARAHMAND, B. (2001). DESIGNING AND SYNTHESIS OF MORPHINE VACCINE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 8(3 (21)), 10-21. https://www.sid.ir/en/journal/ViewPaper.aspx?id=47574



Vancouver: Copy

AKBARZADEH A., FARAHMAND B.. DESIGNING AND SYNTHESIS OF MORPHINE VACCINE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES. 2001 [cited 2022May21];8(3 (21)):10-21. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=47574



IEEE: Copy

AKBARZADEH, A., FARAHMAND, B., 2001. DESIGNING AND SYNTHESIS OF MORPHINE VACCINE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, [online] 8(3 (21)), pp.10-21. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=47574.



 
 
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